Towards a comprehensive recombination map of hotspots in sheep

Cecile Massault; John M Henshall; Cedric Gondro; Julius H Van Der Werf

Towards a comprehensive recombination map of hotspots in sheep

Cecile Massault
, John M Henshall
, Cedric Gondro
, Julius H Van Der Werf

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Recombination rate is positively associated with genetic diversity (Spencer et al. 2006). Hotspots are regions with a higher recombination rate than average, which could be indicative of diversity in the genome. We used genotype data from Illumina OvineSNP50 Bead Chip on 3908 sheep, to first infer sire haplotypes and then detect the recombination events for the whole genome. We found on average over the genome 0.033 recombination events per mega base pair (Mb). Variance of recombination events between individuals was large, but much smaller between sire groups. Breed was found to have a highly significant effect on recombination events over the genome. Heritability of recombination events was found to be medium (0.25 ± 0.09). A recombination map is a useful tool to better understand the mechanisms of diversity, and this information can be used to have more insight in linkage disequilibrium.

Original language	English
Title of host publication	Proceedings of the Association for the Advancement of Animal Breeding and Genetics
Editors	William Pattie
Place of Publication	Armidale, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	375-378
Volume	19
ISBN (Print)	9780646559155
Publication status	Published - 2011
Event	AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics - Perth, Australia Duration: 19 Jul 2011 → 21 Jul 2011

Conference

Conference	AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics
City	Perth, Australia
Period	19/07/11 → 21/07/11

Keywords

Animal Breeding
Quantitative Genetics (incl Disease and Trait Mapping Genetics)

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https://hdl.handle.net/1959.11/10104

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Massault, C., Henshall, J. M., Gondro, C., & Van Der Werf, J. H. (2011). Towards a comprehensive recombination map of hotspots in sheep. In W. Pattie (Ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics (Vol. 19, pp. 375-378). Association for the Advancement of Animal Breeding and Genetics (AAABG). https://hdl.handle.net/1959.11/10104

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title = "Towards a comprehensive recombination map of hotspots in sheep",

abstract = "Recombination rate is positively associated with genetic diversity (Spencer et al. 2006). Hotspots are regions with a higher recombination rate than average, which could be indicative of diversity in the genome. We used genotype data from Illumina OvineSNP50 Bead Chip on 3908 sheep, to first infer sire haplotypes and then detect the recombination events for the whole genome. We found on average over the genome 0.033 recombination events per mega base pair (Mb). Variance of recombination events between individuals was large, but much smaller between sire groups. Breed was found to have a highly significant effect on recombination events over the genome. Heritability of recombination events was found to be medium (0.25 ± 0.09). A recombination map is a useful tool to better understand the mechanisms of diversity, and this information can be used to have more insight in linkage disequilibrium.",

keywords = "Animal Breeding, Quantitative Genetics (incl Disease and Trait Mapping Genetics)",

author = "Cecile Massault and Henshall, \{John M\} and Cedric Gondro and \{Van Der Werf\}, \{Julius H\}",

year = "2011",

language = "English",

isbn = "9780646559155",

volume = "19",

pages = "375--378",

editor = "William Pattie",

booktitle = "Proceedings of the Association for the Advancement of Animal Breeding and Genetics",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

note = "AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics ; Conference date: 19-07-2011 Through 21-07-2011",

}

Massault, C, Henshall, JM, Gondro, C & Van Der Werf, JH 2011, Towards a comprehensive recombination map of hotspots in sheep. in W Pattie (ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics. vol. 19, Association for the Advancement of Animal Breeding and Genetics (AAABG), Armidale, Australia, pp. 375-378, AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics, Perth, Australia, 19/07/11. <https://hdl.handle.net/1959.11/10104>

Towards a comprehensive recombination map of hotspots in sheep. / Massault, Cecile; Henshall, John M; Gondro, Cedric et al.
Proceedings of the Association for the Advancement of Animal Breeding and Genetics. ed. / William Pattie. Vol. 19 Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2011. p. 375-378.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Towards a comprehensive recombination map of hotspots in sheep

AU - Massault, Cecile

AU - Henshall, John M

AU - Gondro, Cedric

AU - Van Der Werf, Julius H

PY - 2011

Y1 - 2011

N2 - Recombination rate is positively associated with genetic diversity (Spencer et al. 2006). Hotspots are regions with a higher recombination rate than average, which could be indicative of diversity in the genome. We used genotype data from Illumina OvineSNP50 Bead Chip on 3908 sheep, to first infer sire haplotypes and then detect the recombination events for the whole genome. We found on average over the genome 0.033 recombination events per mega base pair (Mb). Variance of recombination events between individuals was large, but much smaller between sire groups. Breed was found to have a highly significant effect on recombination events over the genome. Heritability of recombination events was found to be medium (0.25 ± 0.09). A recombination map is a useful tool to better understand the mechanisms of diversity, and this information can be used to have more insight in linkage disequilibrium.

AB - Recombination rate is positively associated with genetic diversity (Spencer et al. 2006). Hotspots are regions with a higher recombination rate than average, which could be indicative of diversity in the genome. We used genotype data from Illumina OvineSNP50 Bead Chip on 3908 sheep, to first infer sire haplotypes and then detect the recombination events for the whole genome. We found on average over the genome 0.033 recombination events per mega base pair (Mb). Variance of recombination events between individuals was large, but much smaller between sire groups. Breed was found to have a highly significant effect on recombination events over the genome. Heritability of recombination events was found to be medium (0.25 ± 0.09). A recombination map is a useful tool to better understand the mechanisms of diversity, and this information can be used to have more insight in linkage disequilibrium.

KW - Animal Breeding

KW - Quantitative Genetics (incl Disease and Trait Mapping Genetics)

UR - http://trove.nla.gov.au/work/162660639

UR - http://www.aaabg.org/aaabg19/

M3 - Conference contribution

SN - 9780646559155

VL - 19

SP - 375

EP - 378

BT - Proceedings of the Association for the Advancement of Animal Breeding and Genetics

A2 - Pattie, William

PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

CY - Armidale, Australia

T2 - AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics

Y2 - 19 July 2011 through 21 July 2011

ER -

Towards a comprehensive recombination map of hotspots in sheep

Abstract

Conference

Keywords

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