The potential for pharmacological supply of 25-hydroxyvitamin D to increase phosphorus utilisation in cattle

Phosphorus (P) is recommended as a supplement for beef cattle grazing rangelands and for dairy cows grazing pastures. However, existing supplementation mechanisms are wasteful, labour intensive, and are becoming increasingly expensive. Cattle have an inability to absorb or retain >70% of the P they consume. Therefore, the need for supplementation could be reduced if the utilisation of dietary P was increased. Vitamin D and its metabolites are involved in the absorption and metabolism of calcium (Ca) and P. However, the use of vitamin D for improving utilisation of P is novel. This review presents information gathered from various studies that demonstrate the potential for vitamin D metabolites to increase P utilisation. The concentration of dietary Ca is demonstrated to be the controlling element for utilisation of endogenous sources of vitamin D. Therefore, the use of exogenous sources of vitamin D in greater than normal concentration is required to overcome the suppression of active absorption mechanisms by normal calcaemia. Use of 25-hydroxyvitamin D in sufficient doses has been shown to increase active absorption of both Ca and P and therefore potentially provide a method of increasing utilisation of existing sources of P or increase the utilisation of P supplements for cattle.