The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population

H D Daetwyler; K E Kemper; Julius H Van Der Werf; B J Hayes

The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population

H D Daetwyler
, K E Kemper
, Julius H Van Der Werf
, B J Hayes

School of Environmental & Rural Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Population structure, due to breed, strains and sire family, influences the accuracy of genomic prediction. We investigated principle component analysis as a way to account for population structure in within and across breed genomic prediction of greasy fleece weight and eye muscle depth in multi-breed sheep data. Population structure (including for example half sib family relationships) is responsible for a large proportion of the accuracy of genomic prediction. Correcting for it increased accuracy of greasy fleece weight across breed prediction, but reduced accuracy of across breed prediction for eye muscle depth for breeds not in the reference set. However, the correction reduced within breed accuracy.

Original language	English
Title of host publication	Proceedings of the Association for the Advancement of Animal Breeding and Genetics
Editors	William Pattie
Place of Publication	Armidale, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	327-330
Volume	19
ISBN (Print)	9780646559155
Publication status	Published - 2011
Event	AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics - Perth, Australia Duration: 19 Jul 2011 → 21 Jul 2011

Conference

Conference	AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics
City	Perth, Australia
Period	19/07/11 → 21/07/11

Keywords

Animal Breeding

Access to Document

https://hdl.handle.net/1959.11/10101

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Daetwyler, H. D., Kemper, K. E., Van Der Werf, J. H., & Hayes, B. J. (2011). The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population. In W. Pattie (Ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics (Vol. 19, pp. 327-330). Association for the Advancement of Animal Breeding and Genetics (AAABG). https://hdl.handle.net/1959.11/10101

Daetwyler, H D ; Kemper, K E ; Van Der Werf, Julius H et al. / The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population. Proceedings of the Association for the Advancement of Animal Breeding and Genetics. editor / William Pattie. Vol. 19 Armidale, Australia : Association for the Advancement of Animal Breeding and Genetics (AAABG), 2011. pp. 327-330

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title = "The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population",

abstract = "Population structure, due to breed, strains and sire family, influences the accuracy of genomic prediction. We investigated principle component analysis as a way to account for population structure in within and across breed genomic prediction of greasy fleece weight and eye muscle depth in multi-breed sheep data. Population structure (including for example half sib family relationships) is responsible for a large proportion of the accuracy of genomic prediction. Correcting for it increased accuracy of greasy fleece weight across breed prediction, but reduced accuracy of across breed prediction for eye muscle depth for breeds not in the reference set. However, the correction reduced within breed accuracy.",

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author = "Daetwyler, \{H D\} and Kemper, \{K E\} and \{Van Der Werf\}, \{Julius H\} and Hayes, \{B J\}",

year = "2011",

language = "English",

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volume = "19",

pages = "327--330",

editor = "William Pattie",

booktitle = "Proceedings of the Association for the Advancement of Animal Breeding and Genetics",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

note = "AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics ; Conference date: 19-07-2011 Through 21-07-2011",

}

Daetwyler, HD, Kemper, KE, Van Der Werf, JH & Hayes, BJ 2011, The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population. in W Pattie (ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics. vol. 19, Association for the Advancement of Animal Breeding and Genetics (AAABG), Armidale, Australia, pp. 327-330, AAABG 2011: 19th Conference of the Association for the Advancement of Animal Breeding and Genetics, Perth, Australia, 19/07/11. <https://hdl.handle.net/1959.11/10101>

The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population. / Daetwyler, H D; Kemper, K E; Van Der Werf, Julius H et al.
Proceedings of the Association for the Advancement of Animal Breeding and Genetics. ed. / William Pattie. Vol. 19 Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2011. p. 327-330.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Population structure, due to breed, strains and sire family, influences the accuracy of genomic prediction. We investigated principle component analysis as a way to account for population structure in within and across breed genomic prediction of greasy fleece weight and eye muscle depth in multi-breed sheep data. Population structure (including for example half sib family relationships) is responsible for a large proportion of the accuracy of genomic prediction. Correcting for it increased accuracy of greasy fleece weight across breed prediction, but reduced accuracy of across breed prediction for eye muscle depth for breeds not in the reference set. However, the correction reduced within breed accuracy.

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UR - http://www.aaabg.org/aaabg19/

M3 - Conference contribution

SN - 9780646559155

VL - 19

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BT - Proceedings of the Association for the Advancement of Animal Breeding and Genetics

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PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

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Daetwyler HD, Kemper KE, Van Der Werf JH, Hayes BJ. The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population. In Pattie W, editor, Proceedings of the Association for the Advancement of Animal Breeding and Genetics. Vol. 19. Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG). 2011. p. 327-330

The importance of population structure on the accuracy of genomic prediction in a multi-breed sheep population

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Conference

Keywords

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