Stress Proteins in Human Breast Cancer

Christopher Shipp; Kenneth Watson; Graham L Jones

Abstract

In this study we investigated stress protein (hsp70 and 90) expression in tumour tissue taken from various breast cancer patients and compared this with expression in a cultured breast cancer cell line as well as in normal peripheral lymphocytes with and without heat shock treatment. Given the importance of hsp90 in the steroid receptor complex we compared the effect of the anticancer drug geldanamycin on the assembly of the hsp90 complex in breast tumour tissue, breast cancer cells and normal lymphocytes in short term culture before and after heat shock.

Original language	English
Pages	114-115
Publication status	Published - 2008
Event	EMBO 2008 Conference: European Molecular Biology Organization 2008 conference on Cellular Signaling and Molecular Medicine - Cavtat, Croatia Duration: 29 May 2008 → 4 Jun 2008

Conference

Conference	EMBO 2008 Conference: European Molecular Biology Organization 2008 conference on Cellular Signaling and Molecular Medicine
City	Cavtat, Croatia
Period	29/05/08 → 4/06/08

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)

Access to Document

https://hdl.handle.net/1959.11/10998

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Persistent link

Cite this

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title = "Stress Proteins in Human Breast Cancer",

abstract = "In this study we investigated stress protein (hsp70 and 90) expression in tumour tissue taken from various breast cancer patients and compared this with expression in a cultured breast cancer cell line as well as in normal peripheral lymphocytes with and without heat shock treatment. Given the importance of hsp90 in the steroid receptor complex we compared the effect of the anticancer drug geldanamycin on the assembly of the hsp90 complex in breast tumour tissue, breast cancer cells and normal lymphocytes in short term culture before and after heat shock.",

keywords = "Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)",

author = "Christopher Shipp and Kenneth Watson and Jones, \{Graham L\}",

year = "2008",

language = "English",

pages = "114--115",

note = "EMBO 2008 Conference: European Molecular Biology Organization 2008 conference on Cellular Signaling and Molecular Medicine ; Conference date: 29-05-2008 Through 04-06-2008",

}

TY - CONF

T1 - Stress Proteins in Human Breast Cancer

AU - Shipp, Christopher

AU - Watson, Kenneth

AU - Jones, Graham L

PY - 2008

Y1 - 2008

N2 - In this study we investigated stress protein (hsp70 and 90) expression in tumour tissue taken from various breast cancer patients and compared this with expression in a cultured breast cancer cell line as well as in normal peripheral lymphocytes with and without heat shock treatment. Given the importance of hsp90 in the steroid receptor complex we compared the effect of the anticancer drug geldanamycin on the assembly of the hsp90 complex in breast tumour tissue, breast cancer cells and normal lymphocytes in short term culture before and after heat shock.

AB - In this study we investigated stress protein (hsp70 and 90) expression in tumour tissue taken from various breast cancer patients and compared this with expression in a cultured breast cancer cell line as well as in normal peripheral lymphocytes with and without heat shock treatment. Given the importance of hsp90 in the steroid receptor complex we compared the effect of the anticancer drug geldanamycin on the assembly of the hsp90 complex in breast tumour tissue, breast cancer cells and normal lymphocytes in short term culture before and after heat shock.

KW - Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics)

M3 - Abstract

SP - 114

EP - 115

T2 - EMBO 2008 Conference: European Molecular Biology Organization 2008 conference on Cellular Signaling and Molecular Medicine

Y2 - 29 May 2008 through 4 June 2008

ER -