Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

Farzana Yousaf; Syed T R Zaidi; Troy Wanandy; Matthew D Jose; Rahul P Patel

doi:10.3747/pdi.2015.00169

Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

Farzana Yousaf
, Syed T R Zaidi
, Troy Wanandy
, Matthew D Jose
, Rahul P Patel

Pharmacy

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

Original language	English
Pages (from-to)	457-459
Journal	Peritoneal Dialysis International
Volume	36
Issue number	4
DOIs	https://doi.org/10.3747/pdi.2015.00169
Publication status	Published - 31 Jul 2016

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title = "Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags",

abstract = "Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90\% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.",

author = "Farzana Yousaf and Zaidi, \{Syed T R\} and Troy Wanandy and Jose, \{Matthew D\} and Patel, \{Rahul P\}",

year = "2016",

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doi = "10.3747/pdi.2015.00169",

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T1 - Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

AU - Yousaf, Farzana

AU - Zaidi, Syed T R

AU - Wanandy, Troy

AU - Jose, Matthew D

AU - Patel, Rahul P

PY - 2016/7/31

Y1 - 2016/7/31

N2 - Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

AB - Intraperitoneal cefepime is used for the treatment of peritoneal dialysis (PD)-associated peritonitis caused by gram-negative bacteria. The current study investigated the stability of cefepime in a pH-neutral PD solution. A reconstituted solution of cefepime was injected into a total of 9 PD bags and stored at 4°C, 25°C or 37°C for various time points. Cefepime retained more than 90% of its initial concentration for 168, 96, and 12 hours at 4°C, 25°C and 37°C, respectively. No apparent physical precipitation or pH change was observed during the study. This study provides crucial information to healthcare professionals on the physical and chemical stability of cefepime in the pH-neutral solution to help them in preparing such admixtures in advance where required.

U2 - 10.3747/pdi.2015.00169

DO - 10.3747/pdi.2015.00169

M3 - Article

SN - 0896-8608

VL - 36

SP - 457

EP - 459

JO - Peritoneal Dialysis International

JF - Peritoneal Dialysis International

IS - 4

ER -

Stability of Cefepime in pH-Neutral Peritoneal Dialysis Solutions Packaged in Dual-Compartment Bags

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