Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Rahul P Patel; Jilson Jacob; Mohammed Sedeeq; Long Chiau Ming; Troy Wanandy; Syed Tabish R Zaidi; Gregory M Peterson

doi:10.1016/j.clinthera.2018.02.009

Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Rahul P Patel
, Jilson Jacob
, Mohammed Sedeeq
, Long Chiau Ming
, Troy Wanandy
, Syed Tabish R Zaidi
, Gregory M Peterson

Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Purpose: The aim was to investigate the stability of cefazolin in elastomeric infusion devices.

Methods: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.

Findings: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.

Implications: These findings will allow the admin-istration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

Original language	English
Pages (from-to)	664-667
Journal	Clinical Therapeutics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1016/j.clinthera.2018.02.009
Publication status	Published - 1 Apr 2018

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10.1016/j.clinthera.2018.02.009

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title = "Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices",

abstract = "Purpose: The aim was to investigate the stability of cefazolin in elastomeric infusion devices. Methods: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content. Findings: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions. Implications: These findings will allow the admin-istration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.",

author = "Patel, \{Rahul P\} and Jilson Jacob and Mohammed Sedeeq and Ming, \{Long Chiau\} and Troy Wanandy and Zaidi, \{Syed Tabish R\} and Peterson, \{Gregory M\}",

year = "2018",

month = apr,

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doi = "10.1016/j.clinthera.2018.02.009",

language = "English",

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TY - JOUR

T1 - Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

AU - Patel, Rahul P

AU - Jacob, Jilson

AU - Sedeeq, Mohammed

AU - Ming, Long Chiau

AU - Wanandy, Troy

AU - Zaidi, Syed Tabish R

AU - Peterson, Gregory M

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Purpose: The aim was to investigate the stability of cefazolin in elastomeric infusion devices. Methods: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content. Findings: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions. Implications: These findings will allow the admin-istration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

AB - Purpose: The aim was to investigate the stability of cefazolin in elastomeric infusion devices. Methods: Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content. Findings: Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions. Implications: These findings will allow the admin-istration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.

U2 - 10.1016/j.clinthera.2018.02.009

DO - 10.1016/j.clinthera.2018.02.009

M3 - Article

SN - 0149-2918

VL - 40

SP - 664

EP - 667

JO - Clinical Therapeutics

JF - Clinical Therapeutics

IS - 4

ER -

Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices

Abstract

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