Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources

KKW Siu; S Sidhu; Gregory Falzon; S Nazaretian; SA Hart; JG Fox; RA Lewis

doi:10.1007/978-3-642-03879-2_170

Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources

KKW Siu, S Sidhu, Gregory Falzon, S Nazaretian, SA Hart, JG Fox, RA Lewis

School of Science & Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

Original language	English
Title of host publication	IFMBE Proceedings
Editors	Olaf Dossel, Wolfgang C Schlegel
Place of Publication	Berlin, Germany
Publisher	International Federation for Medical and Biological Engineering (IFMBE)
Pages	607-610
Volume	25
ISBN (Print)	9783642038792, 9783642038785
DOIs	https://doi.org/10.1007/978-3-642-03879-2_170
Publication status	Published - 2009
Event	WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient - Munich, Germany Duration: 7 Sept 2009 → 12 Sept 2009

Conference

Conference	WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient
City	Munich, Germany
Period	7/09/09 → 12/09/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Medical Physics
Cancer Diagnosis

Access to Document

10.1007/978-3-642-03879-2_170

https://hdl.handle.net/1959.11/8710

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Siu, KKW., Sidhu, S., Falzon, G., Nazaretian, S., Hart, SA., Fox, JG., & Lewis, RA. (2009). Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources. In O. Dossel, & W. C Schlegel (Eds.), IFMBE Proceedings (Vol. 25, pp. 607-610). International Federation for Medical and Biological Engineering (IFMBE). https://doi.org/10.1007/978-3-642-03879-2_170

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title = "Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources",

abstract = "Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.",

keywords = "Medical Physics, Cancer Diagnosis",

author = "KKW Siu and S Sidhu and Gregory Falzon and S Nazaretian and SA Hart and JG Fox and RA Lewis",

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editor = "Olaf Dossel and \{C Schlegel\}, Wolfgang",

booktitle = "IFMBE Proceedings",

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note = "WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient ; Conference date: 07-09-2009 Through 12-09-2009",

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Siu, KKW, Sidhu, S, Falzon, G, Nazaretian, S, Hart, SA, Fox, JG & Lewis, RA 2009, Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources. in O Dossel & W C Schlegel (eds), IFMBE Proceedings. vol. 25, International Federation for Medical and Biological Engineering (IFMBE), Berlin, Germany, pp. 607-610, WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient, Munich, Germany, 7/09/09. https://doi.org/10.1007/978-3-642-03879-2_170

Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources. / Siu, KKW; Sidhu, S; Falzon, Gregory et al.
IFMBE Proceedings. ed. / Olaf Dossel; Wolfgang C Schlegel. Vol. 25 Berlin, Germany: International Federation for Medical and Biological Engineering (IFMBE), 2009. p. 607-610.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Small Angle X-Ray Scattering Signatures for Breast Cancer Detection

T2 - WC 2009: World Congress on Medical Physics and Biomedical Engineering - For the Benefit of the Patient

AU - Siu, KKW

AU - Sidhu, S

AU - Falzon, Gregory

AU - Nazaretian, S

AU - Hart, SA

AU - Fox, JG

AU - Lewis, RA

PY - 2009

Y1 - 2009

N2 - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

AB - Scattering signatures from human breast tissue acquired on a synchrotron x-ray source and a laboratory instrument have been directly compared. We have previously established that the amorphous scatter intensity is extremely sensitive to disease status, able to detect the molecular changes in healthy tissue from patients with verified disease before the conventional histological markers of cancer are visible. SAXS images of tissue samples from 130 patients were imaged on a synchrotron source, and matched samples from 66 of these patients were also imaged on a laboratory source. The results indicate that not only does the integrated amorphous scattering intensity increase with disease severity for both sources, but that the size of the predominant scatterers also appears to decrease with disease progression.

KW - Medical Physics

KW - Cancer Diagnosis

UR - http://trove.nla.gov.au/work/37889433

UR - https://www.scopus.com/pages/publications/77950897680

U2 - 10.1007/978-3-642-03879-2_170

DO - 10.1007/978-3-642-03879-2_170

M3 - Conference contribution

SN - 9783642038792

SN - 9783642038785

VL - 25

SP - 607

EP - 610

BT - IFMBE Proceedings

A2 - Dossel, Olaf

A2 - C Schlegel, Wolfgang

PB - International Federation for Medical and Biological Engineering (IFMBE)

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ER -

Siu KKW, Sidhu S, Falzon G, Nazaretian S, Hart SA, Fox JG et al. Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources. In Dossel O, C Schlegel W, editors, IFMBE Proceedings. Vol. 25. Berlin, Germany: International Federation for Medical and Biological Engineering (IFMBE). 2009. p. 607-610 doi: 10.1007/978-3-642-03879-2_170

Small Angle X-Ray Scattering Signatures for Breast Cancer Detection: Direct Comparison of Synchrotron and Laboratory X-Ray Sources

Abstract

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Keywords

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