Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs

E Piper; Y Chen; Yuandan Zhang; Bruce Tier; Hans Ulrich Graser; B G Luxford; C Moran

Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs

E Piper, Y Chen, Yuandan Zhang, Bruce Tier, Hans Ulrich Graser, B G Luxford, C Moran

Animal Genetics and Breeding Unit

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).

Original language	English
Title of host publication	Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics
Editors	AAABG: Association for the Advancement of Animal Breeding, Genetics
Place of Publication	Armidale, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	53-56
Volume	17
ISBN (Print)	1921208139
Publication status	Published - 2007
Event	AAABG 2007: 17th Conference of the Association for the Advancement of Animal Breeding and Genetics - University of New England, Armidale, Australia Duration: 23 Sept 2007 → 26 Sept 2007

Conference

Conference	AAABG 2007: 17th Conference of the Association for the Advancement of Animal Breeding and Genetics
City	Armidale, Australia
Period	23/09/07 → 26/09/07

Keywords

Quantitative Genetics (incl Disease and Trait Mapping Genetics)

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https://hdl.handle.net/1959.11/4133

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Piper, E., Chen, Y., Zhang, Y., Tier, B., Graser, H. U., Luxford, B. G., & Moran, C. (2007). Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs. In AAABG. Association for the Advancement of Animal Breeding, & Genetics (Eds.), Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics (Vol. 17, pp. 53-56). Association for the Advancement of Animal Breeding and Genetics (AAABG). https://hdl.handle.net/1959.11/4133

Piper, E ; Chen, Y ; Zhang, Yuandan et al. / Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs. Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics. editor / AAABG: Association for the Advancement of Animal Breeding ; Genetics. Vol. 17 Armidale, Australia : Association for the Advancement of Animal Breeding and Genetics (AAABG), 2007. pp. 53-56

@inproceedings{6abed3cfbcc94bf8b36d7915d9bf70da,

title = "Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs",

abstract = "The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).",

keywords = "Quantitative Genetics (incl Disease and Trait Mapping Genetics)",

author = "E Piper and Y Chen and Yuandan Zhang and Bruce Tier and Graser, \{Hans Ulrich\} and Luxford, \{B G\} and C Moran",

year = "2007",

language = "English",

isbn = "1921208139",

volume = "17",

pages = "53--56",

editor = "\{Association for the Advancement of Animal Breeding\}, AAABG: and Genetics",

booktitle = "Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

note = "AAABG 2007: 17th Conference of the Association for the Advancement of Animal Breeding and Genetics ; Conference date: 23-09-2007 Through 26-09-2007",

}

Piper, E, Chen, Y, Zhang, Y, Tier, B, Graser, HU, Luxford, BG & Moran, C 2007, Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs. in AAABG Association for the Advancement of Animal Breeding & Genetics (eds), Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics. vol. 17, Association for the Advancement of Animal Breeding and Genetics (AAABG), Armidale, Australia, pp. 53-56, AAABG 2007: 17th Conference of the Association for the Advancement of Animal Breeding and Genetics, Armidale, Australia, 23/09/07. <https://hdl.handle.net/1959.11/4133>

Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs. / Piper, E; Chen, Y; Zhang, Yuandan et al.
Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics. ed. / AAABG: Association for the Advancement of Animal Breeding; Genetics. Vol. 17 Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2007. p. 53-56.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs

AU - Piper, E

AU - Chen, Y

AU - Zhang, Yuandan

AU - Tier, Bruce

AU - Graser, Hans Ulrich

AU - Luxford, B G

AU - Moran, C

PY - 2007

Y1 - 2007

N2 - The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).

AB - The Suppressor of Cytokine Signalling-2 (SOCS2) is the main negative regulator of somatic growth through the mediation of growth hormone signalling (GH/IGF-1). Knock-out and naturally mutant mice have high growth phenotypes. We have mapped the porcine SOCS2 gene to chromosome 5q, located closely to a reported QTL for food conversion ratio (Lee et al., 2003). Here we report five single nucleotide polymorphisms identified by sequencing of the promoter region and exon 1. One PCR-RFLP assay was designed for genotyping the polymorphism at position 1667(A/G). Association analyses were performed in an Australian mapping resource pedigree (PRDC-US43) for a number of traits (feed conversion ratio, backfat, IGF-1 level and growth traits) and showed significant effects on average daily gain on test (ADG2) (p<0.01) and marginal association with feed conversion ratio (FCR) (p<0.08).

KW - Quantitative Genetics (incl Disease and Trait Mapping Genetics)

UR - http://www.aaabg.org/livestocklibrary/2007/piper053.pdf

UR - http://trove.nla.gov.au/work/35062558?selectedversion=NBD42373479

M3 - Conference contribution

SN - 1921208139

VL - 17

SP - 53

EP - 56

BT - Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics

A2 - Association for the Advancement of Animal Breeding, AAABG:

A2 - Genetics, null

PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

CY - Armidale, Australia

T2 - AAABG 2007: 17th Conference of the Association for the Advancement of Animal Breeding and Genetics

Y2 - 23 September 2007 through 26 September 2007

ER -

Piper E, Chen Y, Zhang Y, Tier B, Graser HU, Luxford BG et al. Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs. In Association for the Advancement of Animal Breeding AAABG, Genetics, editors, Proceedings of the Seventeenth Conference for the Advancement of Animal Breeding and Genetics. Vol. 17. Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG). 2007. p. 53-56

Single nucleotide polymorphisms in suppressor of cytokine signalling-2 gene and association with feed conversion ratio and growth in pigs

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Keywords

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