Sex Differences and Age-Related Decline in Absolute Cerebral Metabolic Rate of Oxygen (CMRO2) Consumption

Rebecca Williams; Alexander Cohen; R Marc Lebel; M Ethan MacDonald; Yang Wang; G Bruce Pike

Abstract

Motivation: Resting CMRO₂ is a marker of brain health that may inform typical and pathological brain aging. However, there is conflicting literature describing how CMRO₂ changes across the lifespan, which may be influenced by extraneous variables such as sex and end-tidal partial pressure of carbon dioxide (P_ETCO₂).

Goal(s): This study aimed to evaluate CMRO₂ changes across the lifespan, after considering these possible confounding variables.

Approach: Dual-calibrated BOLD fMRI quantified grey matter absolute CMRO₂ in 83 participants.

Results: Sex and age significantly predicted CMRO₂. Females had higher CMRO₂ than males, and CMRO₂ decreased with increasing age for females.

Impact: Grey matter CMRO₂ decreases in normal healthy aging. Considering both sexes, the CMRO₂ decline rate was -0.88 per year, after accounting for P_ETCO₂ and sex. When males and females were analysed separately, females only showed a significant decline with age.

Original language	English
Publication status	Published - 31 May 2024
Event	ISMRM/ISMRT 2024: Annual Meeting & Exhibition - Suntec Singapore Convention & Exhibition Centre 1 Raffles Blvd, Singapore 039593, Singapore Duration: 4 May 2024 → 9 May 2024

Other

Other	ISMRM/ISMRT 2024: Annual Meeting & Exhibition
City	Singapore
Period	4/05/24 → 9/05/24

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https://hdl.handle.net/1959.11/64456

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Cite this

@conference{957a016d253449a3b6e49b453c68a599,

title = "Sex Differences and Age-Related Decline in Absolute Cerebral Metabolic Rate of Oxygen (CMRO2) Consumption",

abstract = "Motivation: Resting CMRO2 is a marker of brain health that may inform typical and pathological brain aging. However, there is conflicting literature describing how CMRO2 changes across the lifespan, which may be influenced by extraneous variables such as sex and end-tidal partial pressure of carbon dioxide (PETCO2). Goal(s): This study aimed to evaluate CMRO2 changes across the lifespan, after considering these possible confounding variables. Approach: Dual-calibrated BOLD fMRI quantified grey matter absolute CMRO2 in 83 participants. Results: Sex and age significantly predicted CMRO2. Females had higher CMRO2 than males, and CMRO2 decreased with increasing age for females. Impact: Grey matter CMRO2 decreases in normal healthy aging. Considering both sexes, the CMRO2 decline rate was -0.88 per year, after accounting for PETCO2 and sex. When males and females were analysed separately, females only showed a significant decline with age.",

author = "Rebecca Williams and Alexander Cohen and Lebel, \{R Marc\} and MacDonald, \{M Ethan\} and Yang Wang and Pike, \{G Bruce\}",

year = "2024",

month = may,

day = "31",

language = "English",

note = "ISMRM/ISMRT 2024: Annual Meeting \& Exhibition ; Conference date: 04-05-2024 Through 09-05-2024",

}

TY - CONF

T1 - Sex Differences and Age-Related Decline in Absolute Cerebral Metabolic Rate of Oxygen (CMRO2) Consumption

AU - Williams, Rebecca

AU - Cohen, Alexander

AU - Lebel, R Marc

AU - MacDonald, M Ethan

AU - Wang, Yang

AU - Pike, G Bruce

PY - 2024/5/31

Y1 - 2024/5/31

N2 - Motivation: Resting CMRO2 is a marker of brain health that may inform typical and pathological brain aging. However, there is conflicting literature describing how CMRO2 changes across the lifespan, which may be influenced by extraneous variables such as sex and end-tidal partial pressure of carbon dioxide (PETCO2). Goal(s): This study aimed to evaluate CMRO2 changes across the lifespan, after considering these possible confounding variables. Approach: Dual-calibrated BOLD fMRI quantified grey matter absolute CMRO2 in 83 participants. Results: Sex and age significantly predicted CMRO2. Females had higher CMRO2 than males, and CMRO2 decreased with increasing age for females. Impact: Grey matter CMRO2 decreases in normal healthy aging. Considering both sexes, the CMRO2 decline rate was -0.88 per year, after accounting for PETCO2 and sex. When males and females were analysed separately, females only showed a significant decline with age.

AB - Motivation: Resting CMRO2 is a marker of brain health that may inform typical and pathological brain aging. However, there is conflicting literature describing how CMRO2 changes across the lifespan, which may be influenced by extraneous variables such as sex and end-tidal partial pressure of carbon dioxide (PETCO2). Goal(s): This study aimed to evaluate CMRO2 changes across the lifespan, after considering these possible confounding variables. Approach: Dual-calibrated BOLD fMRI quantified grey matter absolute CMRO2 in 83 participants. Results: Sex and age significantly predicted CMRO2. Females had higher CMRO2 than males, and CMRO2 decreased with increasing age for females. Impact: Grey matter CMRO2 decreases in normal healthy aging. Considering both sexes, the CMRO2 decline rate was -0.88 per year, after accounting for PETCO2 and sex. When males and females were analysed separately, females only showed a significant decline with age.

UR - https://archive.ismrm.org/2024/3445.html

M3 - Abstract

T2 - ISMRM/ISMRT 2024: Annual Meeting & Exhibition

Y2 - 4 May 2024 through 9 May 2024

ER -