Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

JM Behnke; DM Menge; S Nagda; H Noyes; FA Iraqi; SJ Kemp; RJM Mugambi; RL Baker; D Wakelin; John Gibson

doi:10.1017/S0031182009991028

Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

JM Behnke
, DM Menge
, S Nagda
, H Noyes
, FA Iraqi
, SJ Kemp
, RJM Mugambi
, RL Baker
, D Wakelin
, John Gibson

School of Environmental & Rural Science

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to 'Heligmosomoides bakeri'. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to 'H. bakeri' is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

Original language	English
Pages (from-to)	311-320
Journal	Parasitology
Volume	137
Issue number	2
DOIs	https://doi.org/10.1017/S0031182009991028
Publication status	Published - 31 Dec 2010

Keywords

Genetic Immunology

Access to Document

10.1017/S0031182009991028

https://hdl.handle.net/1959.11/9027

Handle.net

Persistent link

Fingerprint

Dive into the research topics of 'Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice'. Together they form a unique fingerprint.

Cite this

Behnke, JM., Menge, DM., Nagda, S., Noyes, H., Iraqi, FA., Kemp, SJ., Mugambi, RJM., Baker, RL., Wakelin, D., & Gibson, J. (2010). Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. Parasitology, 137(2), 311-320. https://doi.org/10.1017/S0031182009991028

@article{7375096d7233444ea603eb82e76fdda9,

title = "Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice",

abstract = "A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to 'Heligmosomoides bakeri'. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to 'H. bakeri' is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.",

keywords = "Genetic Immunology",

author = "JM Behnke and DM Menge and S Nagda and H Noyes and FA Iraqi and SJ Kemp and RJM Mugambi and RL Baker and D Wakelin and John Gibson",

year = "2010",

month = dec,

day = "31",

doi = "10.1017/S0031182009991028",

language = "English",

volume = "137",

pages = "311--320",

journal = "Parasitology",

issn = "0031-1820",

publisher = "Cambridge University Press",

number = "2",

}

Behnke, JM, Menge, DM, Nagda, S, Noyes, H, Iraqi, FA, Kemp, SJ, Mugambi, RJM, Baker, RL, Wakelin, D & Gibson, J 2010, 'Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice', Parasitology, vol. 137, no. 2, pp. 311-320. https://doi.org/10.1017/S0031182009991028

Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice: comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice. / Behnke, JM; Menge, DM; Nagda, S et al.
In: Parasitology, Vol. 137, No. 2, 31.12.2010, p. 311-320.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantitative trait loci for resistance to 'Heligmosomoides bakeri' and associated immunological and pathological traits in mice

T2 - comparison of loci on chromosomes 5, 8 and 11 in F2 and F6/7 inter-cross lines of mice

AU - Behnke, JM

AU - Menge, DM

AU - Nagda, S

AU - Noyes, H

AU - Iraqi, FA

AU - Kemp, SJ

AU - Mugambi, RJM

AU - Baker, RL

AU - Wakelin, D

AU - Gibson, John

PY - 2010/12/31

Y1 - 2010/12/31

N2 - A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to 'Heligmosomoides bakeri'. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to 'H. bakeri' is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

AB - A comparison of F2 and F6/7 inter-cross lines of mice, derived from CBA and SWR parental strains, has provided strong evidence for several previously undetected quantitative trait loci (QTL) for resistance to 'Heligmosomoides bakeri'. Five QTL affecting average faecal egg counts and/or worm burdens in week 6 were detected on mouse chromosomes 5 (Hbnr9 and Hbnr10), 8 (Hbnr11) and 11 (Hbnr13 and Hbnr14). Three QTL for faecal egg counts in weeks 4 and 6 were found on both chromosomes 5 (Hbnr9) and 11 (Hbnr13 and Hbnr14). Two QTL for the mucosal mast cell protease 1 (MCPT1) response were located on chromosomes 8 (Hbnr11) and 11 (Hbnr13), two for the IgG1 antibody response to adult worms on chromosomes 5 (Hbnr10) and 8 (Hbnr11), two for PCV in week 6 on chromosomes 5 (Hbnr9) and 11 (Hbnr13), and two for the granulomatous response on chromosome 8 (Hbnr12) and 11 (Hbnr15). Our data emphasize that the control of resistance to 'H. bakeri' is multigenic, and regulated by genes within QTL regions that have a complex range of hierarchical relationships.

KW - Genetic Immunology

U2 - 10.1017/S0031182009991028

DO - 10.1017/S0031182009991028

M3 - Article

SN - 0031-1820

VL - 137

SP - 311

EP - 320

JO - Parasitology

JF - Parasitology

IS - 2

ER -