Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system

Jonathan M Flintoff; Cassandra Pattinson; Sarah Ahamed; Shahnewaz Ali; Angus Bagley; Daniel Broszczak; Blair Crewther; Louis de Waal; Shannon L Edmed; Tharindu Fernando; Clinton Fookes; Francesca D Frentiu; Andrew P Hunt; Ottmar V Lipp; Ben McMaster; Kerrie Mengersen; Luke Ney; Senn L Oon; Ajay Pandey; Parth Pandit; Jonathan M Peake; Muthukuttige Madusha Nuwanthi Perera; Virginie Perlo; Chamindie Punyadeera; Luke Schmidt; Simon S Smith; Kirsten Spann; Ian Stewart; Karen A Sullivan; Danielle Young; Graham Kerr; Tony J Parker

doi:10.1136/bmjsem-2024-002410

Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system

Jonathan M Flintoff, Cassandra Pattinson, Sarah Ahamed, Shahnewaz Ali, Angus Bagley, Daniel Broszczak, Blair Crewther, Louis de Waal, Shannon L Edmed, Tharindu Fernando, Clinton Fookes, Francesca D Frentiu, Andrew P Hunt, Ottmar V Lipp, Ben McMaster, Kerrie Mengersen, Luke Ney, Senn L Oon, Ajay Pandey, Parth PanditJonathan M Peake, Muthukuttige Madusha Nuwanthi Perera, Virginie Perlo, Chamindie Punyadeera, Luke Schmidt, Simon S Smith, Kirsten Spann, Ian Stewart, Karen A Sullivan, Danielle Young, Graham Kerr, Tony J Parker

Biomedical Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. A within-subjects design will determine changes in molecular and non-molecular markers before and after stress exposure. In Phase II, we will use the biomarkers identified in Phase I to develop a wearable sensor to predict and monitor human performance under stress.

Original language	English
Article number	e002410
Pages (from-to)	1-10
Journal	BMJ Open Sport and Exercise Medicine
Volume	11
Issue number	1
DOIs	https://doi.org/10.1136/bmjsem-2024-002410
Publication status	Published - 20 Jan 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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https://hdl.handle.net/1959.11/72422

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Flintoff, J. M., Pattinson, C., Ahamed, S., Ali, S., Bagley, A., Broszczak, D., Crewther, B., Waal, L. D., Edmed, S. L., Fernando, T., Fookes, C., Frentiu, F. D., Hunt, A. P., Lipp, O. V., McMaster, B., Mengersen, K., Ney, L., Oon, S. L., Pandey, A., ... Parker, T. J. (2025). Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system. BMJ Open Sport and Exercise Medicine, 11(1), 1-10. Article e002410. https://doi.org/10.1136/bmjsem-2024-002410

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abstract = "Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. A within-subjects design will determine changes in molecular and non-molecular markers before and after stress exposure. In Phase II, we will use the biomarkers identified in Phase I to develop a wearable sensor to predict and monitor human performance under stress.",

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Flintoff, JM, Pattinson, C, Ahamed, S, Ali, S, Bagley, A, Broszczak, D, Crewther, B, Waal, LD, Edmed, SL, Fernando, T, Fookes, C, Frentiu, FD, Hunt, AP, Lipp, OV, McMaster, B, Mengersen, K, Ney, L, Oon, SL, Pandey, A, Pandit, P, Peake, JM, Perera, MMN, Perlo, V, Punyadeera, C, Schmidt, L, Smith, SS, Spann, K, Stewart, I, Sullivan, KA, Young, D, Kerr, G & Parker, TJ 2025, 'Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system', BMJ Open Sport and Exercise Medicine, vol. 11, no. 1, e002410, pp. 1-10. https://doi.org/10.1136/bmjsem-2024-002410

TY - JOUR

T1 - Predictive biomarkers of performance under stress

T2 - a two-phase study protocol to develop a wearable monitoring system

AU - Flintoff, Jonathan M

AU - Pattinson, Cassandra

AU - Ahamed, Sarah

AU - Ali, Shahnewaz

AU - Bagley, Angus

AU - Broszczak, Daniel

AU - Crewther, Blair

AU - Waal, Louis de

AU - Edmed, Shannon L

AU - Fernando, Tharindu

AU - Fookes, Clinton

AU - Frentiu, Francesca D

AU - Hunt, Andrew P

AU - Lipp, Ottmar V

AU - McMaster, Ben

AU - Mengersen, Kerrie

AU - Ney, Luke

AU - Oon, Senn L

AU - Pandey, Ajay

AU - Pandit, Parth

AU - Peake, Jonathan M

AU - Perera, Muthukuttige Madusha Nuwanthi

AU - Perlo, Virginie

AU - Punyadeera, Chamindie

AU - Schmidt, Luke

AU - Smith, Simon S

AU - Spann, Kirsten

AU - Stewart, Ian

AU - Sullivan, Karen A

AU - Young, Danielle

AU - Kerr, Graham

AU - Parker, Tony J

PY - 2025/1/20

Y1 - 2025/1/20

N2 - Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. A within-subjects design will determine changes in molecular and non-molecular markers before and after stress exposure. In Phase II, we will use the biomarkers identified in Phase I to develop a wearable sensor to predict and monitor human performance under stress.

AB - Understanding and predicting individual responses to common stressors is essential for optimising performance in high-stress environments. This article outlines a protocol for a study to identify biomarkers that predict performance under heat, musculoskeletal, psychosocial and sleep stress, for future integration into a wearable sensor system. In Phase I, healthy adults aged between 18 and 45 years (n=104) will be recruited for an intervention trial that involves exposure to one of the four stressors: heat, musculoskeletal, psychosocial or sleep deprivation. Biomarkers will be identified from molecular markers in biological samples (eg, blood, saliva, sweat and stool), physiological measures and psychological assessments to predict cognitive and physical performance under stress. A within-subjects design will determine changes in molecular and non-molecular markers before and after stress exposure. In Phase II, we will use the biomarkers identified in Phase I to develop a wearable sensor to predict and monitor human performance under stress.

U2 - 10.1136/bmjsem-2024-002410

DO - 10.1136/bmjsem-2024-002410

M3 - Article

SN - 2055-7647

VL - 11

SP - 1

EP - 10

JO - BMJ Open Sport and Exercise Medicine

JF - BMJ Open Sport and Exercise Medicine

IS - 1

M1 - e002410

ER -

Predictive biomarkers of performance under stress: a two-phase study protocol to develop a wearable monitoring system

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