Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep

Sunduimijid Bolormaa; Julius H Van Der Werf; B J Hayes; M E Goddard; Hans D Daetwyler

Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep

Sunduimijid Bolormaa
, Julius H Van Der Werf
, B J Hayes
, M E Goddard
, Hans D Daetwyler

School of Environmental & Rural Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The aims of this paper were to detect SNP and genes that affect the fatty acid composition and other carcass and meat quality traits in sheep. We performed genome-wide association studies (OW AS) for 56 traits including carcass weights, muscling, fatness, tenderness, meat color, mineral content, and fatty acid composition on 10,613 animals genotyped for 510,174 SNPs. The use of ameta-analysis to combine information from the 56 traits increased the power to detect QTL compared with the single trait analyses. We found pleiotropic QTL, which appear to cluster into 5 functional groups based on their trait effects. Candidate genes were identified in the groups that have functions consistent with the biology of the traits.

Original language	English
Title of host publication	Proceedings of the Association for the Advancement of Animal Breeding and Genetics
Editors	Kim Bunter, Tim Byrne, Hans Daetwyler, Susanne Hermesch, Kathryn Kemper, James Kijas, David Nation, Wayne Pitchford, Suzanne Rowe, Matt Shaffer, Alison van Eenennaam
Place of Publication	Armidale, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	49-52
Volume	21
ISBN (Print)	9780646945545
Publication status	Published - 2015
Event	AAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics - Lorne, Australia Duration: 28 Sept 2015 → 30 Sept 2015

Conference

Conference	AAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics
City	Lorne, Australia
Period	28/09/15 → 30/09/15

Keywords

Animal Breeding

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Bolormaa, S., Van Der Werf, J. H., Hayes, B. J., Goddard, M. E., & Daetwyler, H. D. (2015). Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep. In K. Bunter, T. Byrne, H. Daetwyler, S. Hermesch, K. Kemper, J. Kijas, D. Nation, W. Pitchford, S. Rowe, M. Shaffer, & A. van Eenennaam (Eds.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics (Vol. 21, pp. 49-52). Association for the Advancement of Animal Breeding and Genetics (AAABG). http://www.aaabg.org/aaabghome/AAABG21papers/Bolormaa21049.pdf

Bolormaa, Sunduimijid ; Van Der Werf, Julius H ; Hayes, B J et al. / Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep. Proceedings of the Association for the Advancement of Animal Breeding and Genetics. editor / Kim Bunter ; Tim Byrne ; Hans Daetwyler ; Susanne Hermesch ; Kathryn Kemper ; James Kijas ; David Nation ; Wayne Pitchford ; Suzanne Rowe ; Matt Shaffer ; Alison van Eenennaam. Vol. 21 Armidale, Australia : Association for the Advancement of Animal Breeding and Genetics (AAABG), 2015. pp. 49-52

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title = "Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep",

abstract = "The aims of this paper were to detect SNP and genes that affect the fatty acid composition and other carcass and meat quality traits in sheep. We performed genome-wide association studies (OW AS) for 56 traits including carcass weights, muscling, fatness, tenderness, meat color, mineral content, and fatty acid composition on 10,613 animals genotyped for 510,174 SNPs. The use of ameta-analysis to combine information from the 56 traits increased the power to detect QTL compared with the single trait analyses. We found pleiotropic QTL, which appear to cluster into 5 functional groups based on their trait effects. Candidate genes were identified in the groups that have functions consistent with the biology of the traits.",

keywords = "Animal Breeding",

author = "Sunduimijid Bolormaa and \{Van Der Werf\}, \{Julius H\} and Hayes, \{B J\} and Goddard, \{M E\} and Daetwyler, \{Hans D\}",

year = "2015",

language = "English",

isbn = "9780646945545",

volume = "21",

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booktitle = "Proceedings of the Association for the Advancement of Animal Breeding and Genetics",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

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Bolormaa, S, Van Der Werf, JH, Hayes, BJ, Goddard, ME & Daetwyler, HD 2015, Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep. in K Bunter, T Byrne, H Daetwyler, S Hermesch, K Kemper, J Kijas, D Nation, W Pitchford, S Rowe, M Shaffer & A van Eenennaam (eds), Proceedings of the Association for the Advancement of Animal Breeding and Genetics. vol. 21, Association for the Advancement of Animal Breeding and Genetics (AAABG), Armidale, Australia, pp. 49-52, AAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics, Lorne, Australia, 28/09/15. <http://www.aaabg.org/aaabghome/AAABG21papers/Bolormaa21049.pdf>

Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep. / Bolormaa, Sunduimijid; Van Der Werf, Julius H; Hayes, B J et al.
Proceedings of the Association for the Advancement of Animal Breeding and Genetics. ed. / Kim Bunter; Tim Byrne; Hans Daetwyler; Susanne Hermesch; Kathryn Kemper; James Kijas; David Nation; Wayne Pitchford; Suzanne Rowe; Matt Shaffer; Alison van Eenennaam. Vol. 21 Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2015. p. 49-52.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep

AU - Bolormaa, Sunduimijid

AU - Van Der Werf, Julius H

AU - Hayes, B J

AU - Goddard, M E

AU - Daetwyler, Hans D

PY - 2015

Y1 - 2015

N2 - The aims of this paper were to detect SNP and genes that affect the fatty acid composition and other carcass and meat quality traits in sheep. We performed genome-wide association studies (OW AS) for 56 traits including carcass weights, muscling, fatness, tenderness, meat color, mineral content, and fatty acid composition on 10,613 animals genotyped for 510,174 SNPs. The use of ameta-analysis to combine information from the 56 traits increased the power to detect QTL compared with the single trait analyses. We found pleiotropic QTL, which appear to cluster into 5 functional groups based on their trait effects. Candidate genes were identified in the groups that have functions consistent with the biology of the traits.

AB - The aims of this paper were to detect SNP and genes that affect the fatty acid composition and other carcass and meat quality traits in sheep. We performed genome-wide association studies (OW AS) for 56 traits including carcass weights, muscling, fatness, tenderness, meat color, mineral content, and fatty acid composition on 10,613 animals genotyped for 510,174 SNPs. The use of ameta-analysis to combine information from the 56 traits increased the power to detect QTL compared with the single trait analyses. We found pleiotropic QTL, which appear to cluster into 5 functional groups based on their trait effects. Candidate genes were identified in the groups that have functions consistent with the biology of the traits.

KW - Animal Breeding

UR - http://www.aaabg.org/aaabghome/proceedings21.php

M3 - Conference contribution

SN - 9780646945545

VL - 21

SP - 49

EP - 52

BT - Proceedings of the Association for the Advancement of Animal Breeding and Genetics

A2 - Bunter, Kim

A2 - Byrne, Tim

A2 - Daetwyler, Hans

A2 - Hermesch, Susanne

A2 - Kemper, Kathryn

A2 - Kijas, James

A2 - Nation, David

A2 - Pitchford, Wayne

A2 - Rowe, Suzanne

A2 - Shaffer, Matt

A2 - van Eenennaam, Alison

PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

CY - Armidale, Australia

T2 - AAABG 2015: 21st Conference of the Association for the Advancement of Animal Breeding and Genetics

Y2 - 28 September 2015 through 30 September 2015

ER -

Bolormaa S, Van Der Werf JH, Hayes BJ, Goddard ME, Daetwyler HD. Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep. In Bunter K, Byrne T, Daetwyler H, Hermesch S, Kemper K, Kijas J, Nation D, Pitchford W, Rowe S, Shaffer M, van Eenennaam A, editors, Proceedings of the Association for the Advancement of Animal Breeding and Genetics. Vol. 21. Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG). 2015. p. 49-52

Pleiotropic Multi-Trait Genome-Wide Association Reveals Putative Candidate Genes for Fatty Acid Composition in Australian Sheep

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