Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

Natasha L Williams; Jodie L Morris; Catherine M Rush; Natkunam Ketheesan

doi:10.1016/j.micinf.2014.12.007

Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

Natasha L Williams
, Jodie L Morris
, Catherine M Rush
, Natkunam Ketheesan

Biomedical Science

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.

Original language	English
Pages (from-to)	311-316
Journal	Microbes and Infection
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.micinf.2014.12.007
Publication status	Published - 30 Apr 2015

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https://hdl.handle.net/1959.11/58839

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title = "Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei",

abstract = "Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.",

author = "Williams, \{Natasha L\} and Morris, \{Jodie L\} and Rush, \{Catherine M\} and Natkunam Ketheesan",

year = "2015",

month = apr,

day = "30",

doi = "10.1016/j.micinf.2014.12.007",

language = "English",

volume = "17",

pages = "311--316",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson",

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TY - JOUR

T1 - Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

AU - Williams, Natasha L

AU - Morris, Jodie L

AU - Rush, Catherine M

AU - Ketheesan, Natkunam

PY - 2015/4/30

Y1 - 2015/4/30

N2 - Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.

AB - Melioidosis sepsis, caused by Burkholderia pseudomallei, is associated with high mortality due to an overwhelming inflammatory response. Plasmacytoid dendritic cells (pDC) are potent producers of type I interferons (IFN). This study investigated whether pDC and type I IFN play a role during the early stages of B. pseudomallei infection. Human and murine pDC internalised and killed B. pseudomallei as efficiently as murine conventional DC (cDC). pDC derived from B. pseudomallei-susceptible (BALB/c) mice demonstrated poor intracellular killing and increased IFN-alpha compared to pDC derived from B. pseudomallei-resistant (C57BL/6) mice. This is the first evidence of pDC bactericidal activity against B. pseudomallei infection.

U2 - 10.1016/j.micinf.2014.12.007

DO - 10.1016/j.micinf.2014.12.007

M3 - Article

SN - 1286-4579

VL - 17

SP - 311

EP - 316

JO - Microbes and Infection

JF - Microbes and Infection

IS - 4

ER -

Plasmacytoid dendritic cell bactericidal activity against Burkholderia pseudomallei

Abstract

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