Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Lea K Davis; Dongmei Yu; Cathy L Barr; Dan J Stein; E Strengman; Jay A Tischfield; Ana V Valencia Duarte; Homero Vallada; Filip Van Nieuwerburgh; Jeremy Veenstra-VanderWeele; Susanne Walitza; Allan L Naarden; Chunyu Liu; Christine Lochner; Thomas L Lowe; Fabio Macciardi; Rainald Moessner; James T McCracken; Jubel Morgan; Jian Yang; William Cornejo Ochoa; Jens R Wendland; Heike Muller; Roel A Ophoff; Lisa Osiecki; Andrew J Pakstis; Aline S Sampaio; Michele T Pato; Carlos N Pato; John Piacentini; Sang Hong Lee; Ying Wang; Patrick Evans; Christopher Pittenger; Yehuda Pollak; Scott L Rauch; Tobias J Renner; Victor I Reus; Jack Samuels; Margaret A Richter; Mark A Riddle; Mary M Robertson; Roxana Romero; David Rosenberg; Maria C Rosàrio; Guy A Rouleau; Stephan Ruhrmann; Paul Sandor; Andres Ruiz-Linares; Brooke Sheppard; Harvey S Singer; Laura Bellodi; Carol A Mathews; Jan H Smit; Herman G M Westenberg; Yin Yao Shugart; Euripedes C Miguel; Michael H Bloch; William McMahon; Michael Wagner; Humberto Nicolini; Danielle Posthuma; Gregory L Hanna; James A Knowles; Peter Heutink; Damiaan Denys; Fortu Benarroch; Paul D Arnold; Ben A Oostra; Rianne M Blom; Gerald Nestadt; Nelson B Freimer; David L Pauls; Naomi R Wray; Nancy J Cox; S Evelyn Stewart; Gabriel Bedoya Berrio; Jeremiah M Scharf; Ruth D Bruun; Oscar J Bienvenu; Cathy L Budman; Beatriz Camarena; Clare L Keenan; Patience J Gallagher; Desmond Campbell; Carolina Cappi; Julio C Cardona Silgado; Danielle C Cath; Marco A Grados; Maria C Cavallini; Denise A Chavira; Sylvain Chouinard; David V Conti; Edwin H Cook; Helena Garrido; Vladimir Coric; Eric R Gamazon; Bernadette A Cullen; Dieter Deforce; Richard Delorme; Benjamin D Greenberg; Yves Dion; Christopher K Edlund; Karin Egberts; Peter Falkai; Anuar I Konkashbaev; Thomas V Fernandez; Daniel Geller; Simon L Girard; Varda Gross-Tsur; Hans J Grabe; Stephen Haddad; Gary A Heiman; Sian M J Hemmings; Lauren M McGrath; Ana G Hounie; Eske M Derks; Cornelia Illmann; Joseph Jankovic; Dennis L Murphy; Michael A Jenike; James L Kennedy; Robert A King; Barbara Kremeyer; Roger Kurlan; Sandra C Mesa Restrepo; Nuria Lanzagorta; Marion Leboyer; James F Leckman; Benjamin M Neale; Leonhard Lennertz

doi:10.1371/journal.pgen.1003864

Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

Lea K Davis
, Dongmei Yu
, Cathy L Barr
, Dan J Stein
, E Strengman
, Jay A Tischfield
, Ana V Valencia Duarte
, Homero Vallada
, Filip Van Nieuwerburgh
, Jeremy Veenstra-VanderWeele
, Susanne Walitza
, Allan L Naarden
, Chunyu Liu
, Christine Lochner
, Thomas L Lowe
, Fabio Macciardi
, Rainald Moessner
, James T McCracken
, Jubel Morgan
, Jian Yang

William Cornejo Ochoa, Jens R Wendland, Heike Muller, Roel A Ophoff, Lisa Osiecki, Andrew J Pakstis, Aline S Sampaio, Michele T Pato, Carlos N Pato, John Piacentini, Sang Hong Lee, Ying Wang, Patrick Evans, Christopher Pittenger, Yehuda Pollak, Scott L Rauch, Tobias J Renner, Victor I Reus, Jack Samuels, Margaret A Richter, Mark A Riddle, Mary M Robertson, Roxana Romero, David Rosenberg, Maria C Rosàrio, Guy A Rouleau, Stephan Ruhrmann, Paul Sandor, Andres Ruiz-Linares, Brooke Sheppard, Harvey S Singer, Laura Bellodi, Carol A Mathews, Jan H Smit, Herman G M Westenberg, Yin Yao Shugart, Euripedes C Miguel, Michael H Bloch, William McMahon, Michael Wagner, Humberto Nicolini, Danielle Posthuma, Gregory L Hanna, James A Knowles, Peter Heutink, Damiaan Denys, Fortu Benarroch, Paul D Arnold, Ben A Oostra, Rianne M Blom, Gerald Nestadt, Nelson B Freimer, David L Pauls, Naomi R Wray, Nancy J Cox, S Evelyn Stewart, Gabriel Bedoya Berrio, Jeremiah M Scharf, Ruth D Bruun, Oscar J Bienvenu, Cathy L Budman, Beatriz Camarena, Clare L Keenan, Patience J Gallagher, Desmond Campbell, Carolina Cappi, Julio C Cardona Silgado, Danielle C Cath, Marco A Grados, Maria C Cavallini, Denise A Chavira, Sylvain Chouinard, David V Conti, Edwin H Cook, Helena Garrido, Vladimir Coric, Eric R Gamazon, Bernadette A Cullen, Dieter Deforce, Richard Delorme, Benjamin D Greenberg, Yves Dion, Christopher K Edlund, Karin Egberts, Peter Falkai, Anuar I Konkashbaev, Thomas V Fernandez, Daniel Geller, Simon L Girard, Varda Gross-Tsur, Hans J Grabe, Stephen Haddad, Gary A Heiman, Sian M J Hemmings, Lauren M McGrath, Ana G Hounie, Eske M Derks, Cornelia Illmann, Joseph Jankovic, Dennis L Murphy, Michael A Jenike, James L Kennedy, Robert A King, Barbara Kremeyer, Roger Kurlan, Sandra C Mesa Restrepo, Nuria Lanzagorta, Marion Leboyer, James F Leckman, Benjamin M Neale, Leonhard Lennertz

School of Environmental & Rural Science

Research output: Contribution to journal › Article › peer-review

220 Citations (Scopus)

Original language	English
Article number	e1003864
Pages (from-to)	1-14
Journal	PLoS Genetics
Volume	9
Issue number	10
DOIs	https://doi.org/10.1371/journal.pgen.1003864
Publication status	Published - 2013

Keywords

Gene Expression (incl. Microarray and other genome-wide approaches)

Access to Document

10.1371/journal.pgen.1003864

https://hdl.handle.net/1959.11/22071

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Cite this

Davis, L. K., Yu, D., Barr, C. L., Stein, D. J., Strengman, E., Tischfield, J. A., Valencia Duarte, A. V., Vallada, H., Van Nieuwerburgh, F., Veenstra-VanderWeele, J., Walitza, S., Naarden, A. L., Liu, C., Lochner, C., Lowe, T. L., Macciardi, F., Moessner, R., McCracken, J. T., Morgan, J., ... Lennertz, L. (2013). Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture. PLoS Genetics, 9(10), 1-14. Article e1003864. https://doi.org/10.1371/journal.pgen.1003864

@article{c1b2793b1b024931a5b4aa6b5f5591e5,

title = "Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture",

keywords = "Gene Expression (incl. Microarray and other genome-wide approaches)",

author = "Davis, \{Lea K\} and Dongmei Yu and Barr, \{Cathy L\} and Stein, \{Dan J\} and E Strengman and Tischfield, \{Jay A\} and \{Valencia Duarte\}, \{Ana V\} and Homero Vallada and \{Van Nieuwerburgh\}, Filip and Jeremy Veenstra-VanderWeele and Susanne Walitza and Naarden, \{Allan L\} and Chunyu Liu and Christine Lochner and Lowe, \{Thomas L\} and Fabio Macciardi and Rainald Moessner and McCracken, \{James T\} and Jubel Morgan and Jian Yang and Ochoa, \{William Cornejo\} and Wendland, \{Jens R\} and Heike Muller and Ophoff, \{Roel A\} and Lisa Osiecki and Pakstis, \{Andrew J\} and Sampaio, \{Aline S\} and Pato, \{Michele T\} and Pato, \{Carlos N\} and John Piacentini and Lee, \{Sang Hong\} and Ying Wang and Patrick Evans and Christopher Pittenger and Yehuda Pollak and Rauch, \{Scott L\} and Renner, \{Tobias J\} and Reus, \{Victor I\} and Jack Samuels and Richter, \{Margaret A\} and Riddle, \{Mark A\} and Robertson, \{Mary M\} and Roxana Romero and David Rosenberg and Ros{\`a}rio, \{Maria C\} and Rouleau, \{Guy A\} and Stephan Ruhrmann and Paul Sandor and Andres Ruiz-Linares and Brooke Sheppard and Singer, \{Harvey S\} and Laura Bellodi and Mathews, \{Carol A\} and Smit, \{Jan H\} and Westenberg, \{Herman G M\} and Shugart, \{Yin Yao\} and Miguel, \{Euripedes C\} and Bloch, \{Michael H\} and William McMahon and Michael Wagner and Humberto Nicolini and Danielle Posthuma and Hanna, \{Gregory L\} and Knowles, \{James A\} and Peter Heutink and Damiaan Denys and Fortu Benarroch and Arnold, \{Paul D\} and Oostra, \{Ben A\} and Blom, \{Rianne M\} and Gerald Nestadt and Freimer, \{Nelson B\} and Pauls, \{David L\} and Wray, \{Naomi R\} and Cox, \{Nancy J\} and Stewart, \{S Evelyn\} and Berrio, \{Gabriel Bedoya\} and Scharf, \{Jeremiah M\} and Bruun, \{Ruth D\} and Bienvenu, \{Oscar J\} and Budman, \{Cathy L\} and Beatriz Camarena and Keenan, \{Clare L\} and Gallagher, \{Patience J\} and Desmond Campbell and Carolina Cappi and \{Cardona Silgado\}, \{Julio C\} and Cath, \{Danielle C\} and Grados, \{Marco A\} and Cavallini, \{Maria C\} and Chavira, \{Denise A\} and Sylvain Chouinard and Conti, \{David V\} and Cook, \{Edwin H\} and Helena Garrido and Vladimir Coric and Gamazon, \{Eric R\} and Cullen, \{Bernadette A\} and Dieter Deforce and Richard Delorme and Greenberg, \{Benjamin D\} and Yves Dion and Edlund, \{Christopher K\} and Karin Egberts and Peter Falkai and Konkashbaev, \{Anuar I\} and Fernandez, \{Thomas V\} and Daniel Geller and Girard, \{Simon L\} and Varda Gross-Tsur and Grabe, \{Hans J\} and Stephen Haddad and Heiman, \{Gary A\} and Hemmings, \{Sian M J\} and McGrath, \{Lauren M\} and Hounie, \{Ana G\} and Derks, \{Eske M\} and Cornelia Illmann and Joseph Jankovic and Murphy, \{Dennis L\} and Jenike, \{Michael A\} and Kennedy, \{James L\} and King, \{Robert A\} and Barbara Kremeyer and Roger Kurlan and \{Mesa Restrepo\}, \{Sandra C\} and Nuria Lanzagorta and Marion Leboyer and Leckman, \{James F\} and Neale, \{Benjamin M\} and Leonhard Lennertz",

year = "2013",

doi = "10.1371/journal.pgen.1003864",

language = "English",

volume = "9",

pages = "1--14",

journal = "PLoS Genetics",

issn = "1553-7390",

publisher = "Public Library of Science",

number = "10",

}

Davis, LK, Yu, D, Barr, CL, Stein, DJ, Strengman, E, Tischfield, JA, Valencia Duarte, AV, Vallada, H, Van Nieuwerburgh, F, Veenstra-VanderWeele, J, Walitza, S, Naarden, AL, Liu, C, Lochner, C, Lowe, TL, Macciardi, F, Moessner, R, McCracken, JT, Morgan, J, Yang, J, Ochoa, WC, Wendland, JR, Muller, H, Ophoff, RA, Osiecki, L, Pakstis, AJ, Sampaio, AS, Pato, MT, Pato, CN, Piacentini, J, Lee, SH, Wang, Y, Evans, P, Pittenger, C, Pollak, Y, Rauch, SL, Renner, TJ, Reus, VI, Samuels, J, Richter, MA, Riddle, MA, Robertson, MM, Romero, R, Rosenberg, D, Rosàrio, MC, Rouleau, GA, Ruhrmann, S, Sandor, P, Ruiz-Linares, A, Sheppard, B, Singer, HS, Bellodi, L, Mathews, CA, Smit, JH, Westenberg, HGM, Shugart, YY, Miguel, EC, Bloch, MH, McMahon, W, Wagner, M, Nicolini, H, Posthuma, D, Hanna, GL, Knowles, JA, Heutink, P, Denys, D, Benarroch, F, Arnold, PD, Oostra, BA, Blom, RM, Nestadt, G, Freimer, NB, Pauls, DL, Wray, NR, Cox, NJ, Stewart, SE, Berrio, GB, Scharf, JM, Bruun, RD, Bienvenu, OJ, Budman, CL, Camarena, B, Keenan, CL, Gallagher, PJ, Campbell, D, Cappi, C, Cardona Silgado, JC, Cath, DC, Grados, MA, Cavallini, MC, Chavira, DA, Chouinard, S, Conti, DV, Cook, EH, Garrido, H, Coric, V, Gamazon, ER, Cullen, BA, Deforce, D, Delorme, R, Greenberg, BD, Dion, Y, Edlund, CK, Egberts, K, Falkai, P, Konkashbaev, AI, Fernandez, TV, Geller, D, Girard, SL, Gross-Tsur, V, Grabe, HJ, Haddad, S, Heiman, GA, Hemmings, SMJ, McGrath, LM, Hounie, AG, Derks, EM, Illmann, C, Jankovic, J, Murphy, DL, Jenike, MA, Kennedy, JL, King, RA, Kremeyer, B, Kurlan, R, Mesa Restrepo, SC, Lanzagorta, N, Leboyer, M, Leckman, JF, Neale, BM & Lennertz, L 2013, 'Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture', PLoS Genetics, vol. 9, no. 10, e1003864, pp. 1-14. https://doi.org/10.1371/journal.pgen.1003864

TY - JOUR

T1 - Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture

AU - Davis, Lea K

AU - Yu, Dongmei

AU - Barr, Cathy L

AU - Stein, Dan J

AU - Strengman, E

AU - Tischfield, Jay A

AU - Valencia Duarte, Ana V

AU - Vallada, Homero

AU - Van Nieuwerburgh, Filip

AU - Veenstra-VanderWeele, Jeremy

AU - Walitza, Susanne

AU - Naarden, Allan L

AU - Liu, Chunyu

AU - Lochner, Christine

AU - Lowe, Thomas L

AU - Macciardi, Fabio

AU - Moessner, Rainald

AU - McCracken, James T

AU - Morgan, Jubel

AU - Yang, Jian

AU - Ochoa, William Cornejo

AU - Wendland, Jens R

AU - Muller, Heike

AU - Ophoff, Roel A

AU - Osiecki, Lisa

AU - Pakstis, Andrew J

AU - Sampaio, Aline S

AU - Pato, Michele T

AU - Pato, Carlos N

AU - Piacentini, John

AU - Lee, Sang Hong

AU - Wang, Ying

AU - Evans, Patrick

AU - Pittenger, Christopher

AU - Pollak, Yehuda

AU - Rauch, Scott L

AU - Renner, Tobias J

AU - Reus, Victor I

AU - Samuels, Jack

AU - Richter, Margaret A

AU - Riddle, Mark A

AU - Robertson, Mary M

AU - Romero, Roxana

AU - Rosenberg, David

AU - Rosàrio, Maria C

AU - Rouleau, Guy A

AU - Ruhrmann, Stephan

AU - Sandor, Paul

AU - Ruiz-Linares, Andres

AU - Sheppard, Brooke

AU - Singer, Harvey S

AU - Bellodi, Laura

AU - Mathews, Carol A

AU - Smit, Jan H

AU - Westenberg, Herman G M

AU - Shugart, Yin Yao

AU - Miguel, Euripedes C

AU - Bloch, Michael H

AU - McMahon, William

AU - Wagner, Michael

AU - Nicolini, Humberto

AU - Posthuma, Danielle

AU - Hanna, Gregory L

AU - Knowles, James A

AU - Heutink, Peter

AU - Denys, Damiaan

AU - Benarroch, Fortu

AU - Arnold, Paul D

AU - Oostra, Ben A

AU - Blom, Rianne M

AU - Nestadt, Gerald

AU - Freimer, Nelson B

AU - Pauls, David L

AU - Wray, Naomi R

AU - Cox, Nancy J

AU - Stewart, S Evelyn

AU - Berrio, Gabriel Bedoya

AU - Scharf, Jeremiah M

AU - Bruun, Ruth D

AU - Bienvenu, Oscar J

AU - Budman, Cathy L

AU - Camarena, Beatriz

AU - Keenan, Clare L

AU - Gallagher, Patience J

AU - Campbell, Desmond

AU - Cappi, Carolina

AU - Cardona Silgado, Julio C

AU - Cath, Danielle C

AU - Grados, Marco A

AU - Cavallini, Maria C

AU - Chavira, Denise A

AU - Chouinard, Sylvain

AU - Conti, David V

AU - Cook, Edwin H

AU - Garrido, Helena

AU - Coric, Vladimir

AU - Gamazon, Eric R

AU - Cullen, Bernadette A

AU - Deforce, Dieter

AU - Delorme, Richard

AU - Greenberg, Benjamin D

AU - Dion, Yves

AU - Edlund, Christopher K

AU - Egberts, Karin

AU - Falkai, Peter

AU - Konkashbaev, Anuar I

AU - Fernandez, Thomas V

AU - Geller, Daniel

AU - Girard, Simon L

AU - Gross-Tsur, Varda

AU - Grabe, Hans J

AU - Haddad, Stephen

AU - Heiman, Gary A

AU - Hemmings, Sian M J

AU - McGrath, Lauren M

AU - Hounie, Ana G

AU - Derks, Eske M

AU - Illmann, Cornelia

AU - Jankovic, Joseph

AU - Murphy, Dennis L

AU - Jenike, Michael A

AU - Kennedy, James L

AU - King, Robert A

AU - Kremeyer, Barbara

AU - Kurlan, Roger

AU - Mesa Restrepo, Sandra C

AU - Lanzagorta, Nuria

AU - Leboyer, Marion

AU - Leckman, James F

AU - Neale, Benjamin M

AU - Lennertz, Leonhard

PY - 2013

Y1 - 2013

KW - Gene Expression (incl. Microarray and other genome-wide approaches)

U2 - 10.1371/journal.pgen.1003864

DO - 10.1371/journal.pgen.1003864

M3 - Article

SN - 1553-7390

VL - 9

SP - 1

EP - 14

JO - PLoS Genetics

JF - PLoS Genetics

IS - 10

M1 - e1003864

ER -