N-Acyloxy-N-alkoxyamides - structure, properties, reactivity and biological activity

Stephen Glover

doi:10.1016/S0065-3160(07)42002-0

N-Acyloxy-N-alkoxyamides - structure, properties, reactivity and biological activity

Stephen Glover

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The properties of amides are determinants of the structure and characteristics of a wide range of molecules and particularly those of peptides and proteins. Universally, amides and amide linkages are characterised by a nitrogen that is largely Sp² hybridised and in which the lone pair resides in a 2pz orbital. As a consequence thereis a strong interaction between the amide nitrogen and the carbonyl.

Original language	English
Pages (from-to)	35-123
Journal	Advances in Physical Organic Chemistry
Volume	42
DOIs	https://doi.org/10.1016/S0065-3160(07)42002-0
Publication status	Published - 31 Dec 2007

Keywords

Biologically Active Molecules

Access to Document

10.1016/S0065-3160(07)42002-0

https://hdl.handle.net/1959.11/1620

Handle.net

Persistent link

Cite this

@article{23e6f8adb3b549f48c1850bedb705102,

title = "N-Acyloxy-N-alkoxyamides - structure, properties, reactivity and biological activity",

abstract = "The properties of amides are determinants of the structure and characteristics of a wide range of molecules and particularly those of peptides and proteins. Universally, amides and amide linkages are characterised by a nitrogen that is largely Sp² hybridised and in which the lone pair resides in a 2pz orbital. As a consequence thereis a strong interaction between the amide nitrogen and the carbonyl.",

keywords = "Biologically Active Molecules",

author = "Stephen Glover",

year = "2007",

month = dec,

day = "31",

doi = "10.1016/S0065-3160(07)42002-0",

language = "English",

volume = "42",

pages = "35--123",

journal = "Advances in Physical Organic Chemistry",

issn = "0065-3160",

publisher = "Academic Press",

}

TY - JOUR

T1 - N-Acyloxy-N-alkoxyamides - structure, properties, reactivity and biological activity

AU - Glover, Stephen

PY - 2007/12/31

Y1 - 2007/12/31

N2 - The properties of amides are determinants of the structure and characteristics of a wide range of molecules and particularly those of peptides and proteins. Universally, amides and amide linkages are characterised by a nitrogen that is largely Sp² hybridised and in which the lone pair resides in a 2pz orbital. As a consequence thereis a strong interaction between the amide nitrogen and the carbonyl.

AB - The properties of amides are determinants of the structure and characteristics of a wide range of molecules and particularly those of peptides and proteins. Universally, amides and amide linkages are characterised by a nitrogen that is largely Sp² hybridised and in which the lone pair resides in a 2pz orbital. As a consequence thereis a strong interaction between the amide nitrogen and the carbonyl.

KW - Biologically Active Molecules

U2 - 10.1016/S0065-3160(07)42002-0

DO - 10.1016/S0065-3160(07)42002-0

M3 - Article

SN - 0065-3160

VL - 42

SP - 35

EP - 123

JO - Advances in Physical Organic Chemistry

JF - Advances in Physical Organic Chemistry

ER -

N-Acyloxy-N-alkoxyamides - structure, properties, reactivity and biological activity

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this