Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

Lewis A Fraser; Yee-Wai Cheung; Andrew B Kinghorn; Wei Guo; Simon Chi-Chin Shiu; Chandra Jinata; Mengping Liu; Soubhagya Bhuyan; Lang Nan; Ho Cheung Shum; Julian A Tanner

doi:10.1002/adbi.201900012

Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

Lewis A Fraser
, Yee-Wai Cheung
, Andrew B Kinghorn
, Wei Guo
, Simon Chi-Chin Shiu
, Chandra Jinata
, Mengping Liu
, Soubhagya Bhuyan
, Lang Nan
, Ho Cheung Shum
, Julian A Tanner

Animal Science

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern-day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer-based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.

Original language	English
Article number	1900012
Pages (from-to)	1-16
Journal	Advanced biosystems
Volume	3
Issue number	5
DOIs	https://doi.org/10.1002/adbi.201900012
Publication status	Published - 31 May 2019

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https://hdl.handle.net/1959.11/72517

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abstract = "The intersection of microfluidics and aptamer technologies holds particular promise for rapid progress in a plethora of applications across biomedical science and other areas. Here, the influence of microfluidics on the field of aptamers, from traditional capillary electrophoresis approaches through innovative modern-day approaches using micromagnetic beads and emulsion droplets, is reviewed. Miniaturizing aptamer-based bioassays through microfluidics has the potential to transform diagnostics and embedded biosensing in the coming years.",

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AU - Cheung, Yee-Wai

AU - Kinghorn, Andrew B

AU - Guo, Wei

AU - Shiu, Simon Chi-Chin

AU - Jinata, Chandra

AU - Liu, Mengping

AU - Bhuyan, Soubhagya

AU - Nan, Lang

AU - Shum, Ho Cheung

AU - Tanner, Julian A

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Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application

Abstract

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