Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

Charmaine Hee; Diwei Ho; Amir Karton; Gareth Nealon; Jessica A Kretzmann; Marck Norret; K Swaminathan Iyer

doi:10.1039/c9cc06603a

Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

Charmaine Hee
, Diwei Ho
, Amir Karton
, Gareth Nealon
, Jessica A Kretzmann
, Marck Norret
, K Swaminathan Iyer

Faculty of Science, Ag, Business and Law

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells.

Original language	English
Pages (from-to)	14506-14509
Journal	Chemical Communications
Volume	55
Issue number	96
Early online date	15 Nov 2019
DOIs	https://doi.org/10.1039/c9cc06603a
Publication status	Published - 14 Dec 2019

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abstract = "Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells.",

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AU - Ho, Diwei

AU - Karton, Amir

AU - Nealon, Gareth

AU - Kretzmann, Jessica A

AU - Norret, Marck

AU - Iyer, K Swaminathan

PY - 2019/12/14

Y1 - 2019/12/14

N2 - Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells.

AB - Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells.

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DO - 10.1039/c9cc06603a

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JO - Chemical Communications

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Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

Abstract

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