Keeping it simple: lessons from the golden era of antibiotic discovery

Dane Lyddiard; Graham L Jones; Ben Greatrex

doi:10.1093/femsle/fnw084

Keeping it simple: lessons from the golden era of antibiotic discovery

Dane Lyddiard
, Graham L Jones
, Ben Greatrex

Research output: Contribution to journal › Article

45 Citations (Scopus)

Abstract

Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success.

Original language	English
Article number	fnw084
Pages (from-to)	1-3
Journal	FEMS Microbiology Letters
Volume	363
Issue number	8
DOIs	https://doi.org/10.1093/femsle/fnw084
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Pharmacology and Pharmaceutical Sciences
Medical and Health Sciences
Medical Bacteriology

Access to Document

10.1093/femsle/fnw084

https://hdl.handle.net/1959.11/19190

Handle.net

Persistent link

Cite this

@article{26deff0039bd447eb62da72aab5f8a8b,

title = "Keeping it simple: lessons from the golden era of antibiotic discovery",

abstract = "Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success.",

keywords = "Pharmacology and Pharmaceutical Sciences, Medical and Health Sciences, Medical Bacteriology",

author = "Dane Lyddiard and Jones, \{Graham L\} and Ben Greatrex",

year = "2016",

doi = "10.1093/femsle/fnw084",

language = "English",

volume = "363",

pages = "1--3",

journal = "FEMS Microbiology Letters",

issn = "0378-1097",

publisher = "Oxford University Press",

number = "8",

}

TY - JOUR

T1 - Keeping it simple

T2 - lessons from the golden era of antibiotic discovery

AU - Lyddiard, Dane

AU - Jones, Graham L

AU - Greatrex, Ben

PY - 2016

Y1 - 2016

N2 - Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success.

AB - Bacteria are becoming increasingly resistant to currently used antibiotics. At the same time, little progress has been made in discovering new antibacterial drugs to combat resistant organisms. History teaches us that 'high tech' target-based complex methods are not synonymous with success and a return to simple, systematic screening of natural products against bacteria from traditional and novel resources holds our greatest hope of success.

KW - Pharmacology and Pharmaceutical Sciences

KW - Medical and Health Sciences

KW - Medical Bacteriology

U2 - 10.1093/femsle/fnw084

DO - 10.1093/femsle/fnw084

M3 - Article

SN - 0378-1097

VL - 363

SP - 1

EP - 3

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

IS - 8

M1 - fnw084

ER -

Keeping it simple: lessons from the golden era of antibiotic discovery

Abstract

UN SDGs

Keywords

Access to Document

Handle.net

Fingerprint

Cite this