In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines

Srdjan Mijajlovic; Graham L Jones; P Parsons; Kenneth Watson

Abstract

We have studied the effects of extracts of various arid zone Eremophila species native to Australia as well as several other native plant species that have played an important role in the pharmacopoeia of Australian aboriginal people. Recent studies have identified Eremophila spp as potential antibacterial and antiviral agents by the current literature has little information concerning anticancer activity. Plant extracts were tested for activity against three common cancer cell lines: ovarian cancer cells C180-13S, prostate cancer cells DU 145 and human melanoma cells MM96L. Activity against these cancer cell lines was compared to cytotoxicity against primary untransformed human foreskin fibroblasts NFF. Ethanolic plant extracts were applied in serial dilution to microtitre 96 well plates seeded with 5000 cells/well. After six days of incubation the Sulfuorhodamine B cell growth assay was performed. Although all plant extracts exhibited substantial general cytotoxicity, an extract of 'Eremophila duttonnii' exhibited 26 times higher activity against cancer cell lines as compared to normal cells.

Original language	English
Pages	319-319
Publication status	Published - 2005
Event	GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF) - Florence, Italy Duration: 21 Aug 2005 → 25 Aug 2005

Conference

Conference	GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF)
City	Florence, Italy
Period	21/08/05 → 25/08/05

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer Therapy (excl Chemotherapy and Radiation Therapy)

Access to Document

https://hdl.handle.net/1959.11/10994

Handle.net

Persistent link

Cite this

Mijajlovic, S., Jones, G. L., Parsons, P., & Watson, K. (2005). In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines. 319-319. Abstract from GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF), Florence, Italy. https://hdl.handle.net/1959.11/10994

@conference{56c5bd75533b415d8b964205a27df61f,

title = "In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines",

abstract = "We have studied the effects of extracts of various arid zone Eremophila species native to Australia as well as several other native plant species that have played an important role in the pharmacopoeia of Australian aboriginal people. Recent studies have identified Eremophila spp as potential antibacterial and antiviral agents by the current literature has little information concerning anticancer activity. Plant extracts were tested for activity against three common cancer cell lines: ovarian cancer cells C180-13S, prostate cancer cells DU 145 and human melanoma cells MM96L. Activity against these cancer cell lines was compared to cytotoxicity against primary untransformed human foreskin fibroblasts NFF. Ethanolic plant extracts were applied in serial dilution to microtitre 96 well plates seeded with 5000 cells/well. After six days of incubation the Sulfuorhodamine B cell growth assay was performed. Although all plant extracts exhibited substantial general cytotoxicity, an extract of 'Eremophila duttonnii' exhibited 26 times higher activity against cancer cell lines as compared to normal cells.",

keywords = "Cancer Therapy (excl Chemotherapy and Radiation Therapy)",

author = "Srdjan Mijajlovic and Jones, \{Graham L\} and P Parsons and Kenneth Watson",

year = "2005",

language = "English",

pages = "319--319",

note = "GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF) ; Conference date: 21-08-2005 Through 25-08-2005",

}

Mijajlovic, S, Jones, GL, Parsons, P & Watson, K 2005, 'In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines', GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF), Florence, Italy, 21/08/05 - 25/08/05 pp. 319-319. <https://hdl.handle.net/1959.11/10994>

In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines. / Mijajlovic, Srdjan; Jones, Graham L; Parsons, P et al.
2005. 319-319 Abstract from GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF), Florence, Italy.

Research output: Contribution to conference › Abstract

TY - CONF

T1 - In vitro screening of Australian traditional medicinal plants for activity against cancer cell lines

AU - Mijajlovic, Srdjan

AU - Jones, Graham L

AU - Parsons, P

AU - Watson, Kenneth

PY - 2005

Y1 - 2005

N2 - We have studied the effects of extracts of various arid zone Eremophila species native to Australia as well as several other native plant species that have played an important role in the pharmacopoeia of Australian aboriginal people. Recent studies have identified Eremophila spp as potential antibacterial and antiviral agents by the current literature has little information concerning anticancer activity. Plant extracts were tested for activity against three common cancer cell lines: ovarian cancer cells C180-13S, prostate cancer cells DU 145 and human melanoma cells MM96L. Activity against these cancer cell lines was compared to cytotoxicity against primary untransformed human foreskin fibroblasts NFF. Ethanolic plant extracts were applied in serial dilution to microtitre 96 well plates seeded with 5000 cells/well. After six days of incubation the Sulfuorhodamine B cell growth assay was performed. Although all plant extracts exhibited substantial general cytotoxicity, an extract of 'Eremophila duttonnii' exhibited 26 times higher activity against cancer cell lines as compared to normal cells.

AB - We have studied the effects of extracts of various arid zone Eremophila species native to Australia as well as several other native plant species that have played an important role in the pharmacopoeia of Australian aboriginal people. Recent studies have identified Eremophila spp as potential antibacterial and antiviral agents by the current literature has little information concerning anticancer activity. Plant extracts were tested for activity against three common cancer cell lines: ovarian cancer cells C180-13S, prostate cancer cells DU 145 and human melanoma cells MM96L. Activity against these cancer cell lines was compared to cytotoxicity against primary untransformed human foreskin fibroblasts NFF. Ethanolic plant extracts were applied in serial dilution to microtitre 96 well plates seeded with 5000 cells/well. After six days of incubation the Sulfuorhodamine B cell growth assay was performed. Although all plant extracts exhibited substantial general cytotoxicity, an extract of 'Eremophila duttonnii' exhibited 26 times higher activity against cancer cell lines as compared to normal cells.

KW - Cancer Therapy (excl Chemotherapy and Radiation Therapy)

UR - http://www.farmacia.unifi.it/gacongress2005

M3 - Abstract

SP - 319

EP - 319

T2 - GA 2005: 53rd International Congress and Annual Meeting of the Society for Medicinal Plant Research, a joint meeting with Italian Phytochemical Society (SIF)

Y2 - 21 August 2005 through 25 August 2005

ER -