Identifying markers of pathology in SAXS data of malignant tissues of the brain

KKW Siu; SM Butler; AR Round; E Schultke; GI Webb; SJ Wilkinson; T Beveridge; JE Gillam; CJ Hall; AH Kaye; RA Lewis; K Mannan; G McLoughlin; Sarah Jayne Pearson

doi:10.1016/j.nima.2005.03.081

Identifying markers of pathology in SAXS data of malignant tissues of the brain

KKW Siu
, SM Butler
, AR Round
, E Schultke
, GI Webb
, SJ Wilkinson
, T Beveridge
, JE Gillam
, CJ Hall
, AH Kaye
, RA Lewis
, K Mannan
, G McLoughlin
, Sarah Jayne Pearson

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Conventional neuropathological analysis for brain malignancies is heavily reliant on the observation of morphological abnormalities, observed in thin, stained sections of tissue. Small Angle X-ray Scattering (SAXS) data provide an alternative means of distinguishing pathology by examining the ultra-structural (nanometer length scales) characteristics of tissue. To evaluate the diagnostic potential of SAXS for brain tumors, data was collected from normal, malignant and benign tissues of the human brain at station 2.1 of the Daresbury Laboratory Synchrotron Radiation Source and subjected to data mining and multivariate statistical analysis. The results suggest SAXS data may be an effective classifier of malignancy.

Original language	English
Pages (from-to)	140-146
Journal	Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment
Volume	548
Issue number	1-2
DOIs	https://doi.org/10.1016/j.nima.2005.03.081
Publication status	Published - 2005

Keywords

Medical Physics

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10.1016/j.nima.2005.03.081

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Siu, KKW., Butler, SM., Round, AR., Schultke, E., Webb, GI., Wilkinson, SJ., Beveridge, T., Gillam, JE., Hall, CJ., Kaye, AH., Lewis, RA., Mannan, K., McLoughlin, G., & Pearson, S. J. (2005). Identifying markers of pathology in SAXS data of malignant tissues of the brain. Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment, 548(1-2), 140-146. https://doi.org/10.1016/j.nima.2005.03.081

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title = "Identifying markers of pathology in SAXS data of malignant tissues of the brain",

abstract = "Conventional neuropathological analysis for brain malignancies is heavily reliant on the observation of morphological abnormalities, observed in thin, stained sections of tissue. Small Angle X-ray Scattering (SAXS) data provide an alternative means of distinguishing pathology by examining the ultra-structural (nanometer length scales) characteristics of tissue. To evaluate the diagnostic potential of SAXS for brain tumors, data was collected from normal, malignant and benign tissues of the human brain at station 2.1 of the Daresbury Laboratory Synchrotron Radiation Source and subjected to data mining and multivariate statistical analysis. The results suggest SAXS data may be an effective classifier of malignancy.",

keywords = "Medical Physics",

author = "KKW Siu and SM Butler and AR Round and E Schultke and GI Webb and SJ Wilkinson and T Beveridge and JE Gillam and CJ Hall and AH Kaye and RA Lewis and K Mannan and G McLoughlin and Pearson, \{Sarah Jayne\}",

year = "2005",

doi = "10.1016/j.nima.2005.03.081",

language = "English",

volume = "548",

pages = "140--146",

journal = "Nuclear Instruments \& Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment",

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Siu, KKW, Butler, SM, Round, AR, Schultke, E, Webb, GI, Wilkinson, SJ, Beveridge, T, Gillam, JE, Hall, CJ, Kaye, AH, Lewis, RA, Mannan, K, McLoughlin, G & Pearson, SJ 2005, 'Identifying markers of pathology in SAXS data of malignant tissues of the brain', Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment, vol. 548, no. 1-2, pp. 140-146. https://doi.org/10.1016/j.nima.2005.03.081

TY - JOUR

T1 - Identifying markers of pathology in SAXS data of malignant tissues of the brain

AU - Siu, KKW

AU - Butler, SM

AU - Round, AR

AU - Schultke, E

AU - Webb, GI

AU - Wilkinson, SJ

AU - Beveridge, T

AU - Gillam, JE

AU - Hall, CJ

AU - Kaye, AH

AU - Lewis, RA

AU - Mannan, K

AU - McLoughlin, G

AU - Pearson, Sarah Jayne

PY - 2005

Y1 - 2005

N2 - Conventional neuropathological analysis for brain malignancies is heavily reliant on the observation of morphological abnormalities, observed in thin, stained sections of tissue. Small Angle X-ray Scattering (SAXS) data provide an alternative means of distinguishing pathology by examining the ultra-structural (nanometer length scales) characteristics of tissue. To evaluate the diagnostic potential of SAXS for brain tumors, data was collected from normal, malignant and benign tissues of the human brain at station 2.1 of the Daresbury Laboratory Synchrotron Radiation Source and subjected to data mining and multivariate statistical analysis. The results suggest SAXS data may be an effective classifier of malignancy.

AB - Conventional neuropathological analysis for brain malignancies is heavily reliant on the observation of morphological abnormalities, observed in thin, stained sections of tissue. Small Angle X-ray Scattering (SAXS) data provide an alternative means of distinguishing pathology by examining the ultra-structural (nanometer length scales) characteristics of tissue. To evaluate the diagnostic potential of SAXS for brain tumors, data was collected from normal, malignant and benign tissues of the human brain at station 2.1 of the Daresbury Laboratory Synchrotron Radiation Source and subjected to data mining and multivariate statistical analysis. The results suggest SAXS data may be an effective classifier of malignancy.

KW - Medical Physics

U2 - 10.1016/j.nima.2005.03.081

DO - 10.1016/j.nima.2005.03.081

M3 - Article

SN - 0168-9002

VL - 548

SP - 140

EP - 146

JO - Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment

JF - Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment

IS - 1-2

ER -

Identifying markers of pathology in SAXS data of malignant tissues of the brain

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