Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle

Sara de las Heras-Saldana; Naomi Duijvesteijn; Sam Clark; Julius van der Werf; Cedric Gondro; Yizhou Chen

Abstract

The aim of this study was to identify quantitative trait loci (QTL) associated with residual feed intake (RFI) and genes whose expression varied significantly with phenotypic differences in RFI. We used data from 2,190 Angus steers with phenotypic records for RFI, all with imputed high density array (770k) genotypes. We used RNA-seq in a multi-tissue experiment from 126 Angus steers divergently selected for RFI for approximately three generations, to analyze the expression of genes significantly associated (GSA) with RFI, with special attention to the genes close by significant QTLs.

Original language	English
Pages	35-36
Publication status	Published - 2018
Event	ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop - National Wine Centre of Australia, Adelaide, Australia Duration: 12 Nov 2018 → 15 Nov 2018

Conference

Conference	ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop
City	Adelaide, Australia
Period	12/11/18 → 15/11/18

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https://hdl.handle.net/1959.11/53173

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de las Heras-Saldana, S., Duijvesteijn, N., Clark, S., van der Werf, J., Gondro, C., & Chen, Y. (2018). Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle. 35-36. Abstract from ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop, Adelaide, Australia. https://hdl.handle.net/1959.11/53173

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title = "Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle",

abstract = "The aim of this study was to identify quantitative trait loci (QTL) associated with residual feed intake (RFI) and genes whose expression varied significantly with phenotypic differences in RFI. We used data from 2,190 Angus steers with phenotypic records for RFI, all with imputed high density array (770k) genotypes. We used RNA-seq in a multi-tissue experiment from 126 Angus steers divergently selected for RFI for approximately three generations, to analyze the expression of genes significantly associated (GSA) with RFI, with special attention to the genes close by significant QTLs.",

author = "\{de las Heras-Saldana\}, Sara and Naomi Duijvesteijn and Sam Clark and \{van der Werf\}, Julius and Cedric Gondro and Yizhou Chen",

year = "2018",

language = "English",

pages = "35--36",

note = "ISAFG \& FAANG 2018: 7th International Symposium on Animal Functional Genomics \& Functional Annotation of Animal Genomes Workshop ; Conference date: 12-11-2018 Through 15-11-2018",

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de las Heras-Saldana, S, Duijvesteijn, N, Clark, S, van der Werf, J, Gondro, C & Chen, Y 2018, 'Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle', ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop, Adelaide, Australia, 12/11/18 - 15/11/18 pp. 35-36. <https://hdl.handle.net/1959.11/53173>

Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle. / de las Heras-Saldana, Sara; Duijvesteijn, Naomi; Clark, Sam et al.
2018. 35-36 Abstract from ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop, Adelaide, Australia.

Research output: Contribution to conference › Abstract

TY - CONF

T1 - Genome-wide association and gene expression studies to decipher the genetics of residual feed intake in Angus cattle

AU - de las Heras-Saldana, Sara

AU - Duijvesteijn, Naomi

AU - Clark, Sam

AU - van der Werf, Julius

AU - Gondro, Cedric

AU - Chen, Yizhou

PY - 2018

Y1 - 2018

N2 - The aim of this study was to identify quantitative trait loci (QTL) associated with residual feed intake (RFI) and genes whose expression varied significantly with phenotypic differences in RFI. We used data from 2,190 Angus steers with phenotypic records for RFI, all with imputed high density array (770k) genotypes. We used RNA-seq in a multi-tissue experiment from 126 Angus steers divergently selected for RFI for approximately three generations, to analyze the expression of genes significantly associated (GSA) with RFI, with special attention to the genes close by significant QTLs.

AB - The aim of this study was to identify quantitative trait loci (QTL) associated with residual feed intake (RFI) and genes whose expression varied significantly with phenotypic differences in RFI. We used data from 2,190 Angus steers with phenotypic records for RFI, all with imputed high density array (770k) genotypes. We used RNA-seq in a multi-tissue experiment from 126 Angus steers divergently selected for RFI for approximately three generations, to analyze the expression of genes significantly associated (GSA) with RFI, with special attention to the genes close by significant QTLs.

M3 - Abstract

SP - 35

EP - 36

T2 - ISAFG & FAANG 2018: 7th International Symposium on Animal Functional Genomics & Functional Annotation of Animal Genomes Workshop

Y2 - 12 November 2018 through 15 November 2018

ER -