Formation of distinct iron hydrides via mechanistic divergence in directed C–H Bond activation of aryl ketones, esters and amides

Directing groups play an important role in controlling the selectivity of C–H bond activation. Here we demonstrate that for iron, the nature of the directing group (e.g., ketone, ester, or amide) influences the C–H activation process. In this study the C–H bond activation step either occurs with or without the assistance of the directing group resulting in distinct cis- and trans-isomers of the corresponding iron hydride.