Fluoroquinolones

Renee Dimond; Rahul P Patel; Syed Tabish R Zaidi

doi:10.1007/978-3-319-44034-7_5

Fluoroquinolones

Renee Dimond
, Rahul P Patel
, Syed Tabish R Zaidi

Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Research › peer-review

Abstract

Fluoroquinolone antibiotics are frequently used in a variety of indications in hospital and outpatient settings due to the availability of an oral dosage form. The pharmacokinetics of this particular class of antibiotics varies significantly among individual agents, thus preventing a uniform approach to dose adjustment. Relatively more data is available for ciprofloxacin and levofloxacin compared to other agents in this class. This chapter outlines the available literature of pharmacokinetic changes in obese patients and the recommend dosing for specific agents. Flouroquinolone antibiotics have significant dose related adverse effects and therefore, the clinical need of a flouroquinolone should be carefully considered before using them in obese patients, who are likely to receive higher than the usually recommended doses.

Original language	English
Title of host publication	Drug Dosing in Obesity: Volume I: Antimicrobials
Editors	Syed Tabish R Zaidi, Jason A Roberts
Place of Publication	Switzerland
Pages	45-52
Edition	1
DOIs	https://doi.org/10.1007/978-3-319-44034-7_5
Publication status	Published - 27 Sept 2016

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abstract = "Fluoroquinolone antibiotics are frequently used in a variety of indications in hospital and outpatient settings due to the availability of an oral dosage form. The pharmacokinetics of this particular class of antibiotics varies significantly among individual agents, thus preventing a uniform approach to dose adjustment. Relatively more data is available for ciprofloxacin and levofloxacin compared to other agents in this class. This chapter outlines the available literature of pharmacokinetic changes in obese patients and the recommend dosing for specific agents. Flouroquinolone antibiotics have significant dose related adverse effects and therefore, the clinical need of a flouroquinolone should be carefully considered before using them in obese patients, who are likely to receive higher than the usually recommended doses.",

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AU - Patel, Rahul P

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AB - Fluoroquinolone antibiotics are frequently used in a variety of indications in hospital and outpatient settings due to the availability of an oral dosage form. The pharmacokinetics of this particular class of antibiotics varies significantly among individual agents, thus preventing a uniform approach to dose adjustment. Relatively more data is available for ciprofloxacin and levofloxacin compared to other agents in this class. This chapter outlines the available literature of pharmacokinetic changes in obese patients and the recommend dosing for specific agents. Flouroquinolone antibiotics have significant dose related adverse effects and therefore, the clinical need of a flouroquinolone should be carefully considered before using them in obese patients, who are likely to receive higher than the usually recommended doses.

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ER -

Fluoroquinolones

Abstract

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