Fluorescent Angiotensin AT₁ Receptor Antagonists

Marilena A Giarrusso; Michelle K Taylor; James Ziogas; Kate M Brody; Phoebe E Macdougall; Carl H Schiesser

doi:10.1002/ajoc.201200064

Fluorescent Angiotensin AT₁ Receptor Antagonists

Marilena A Giarrusso
, Michelle K Taylor
, James Ziogas
, Kate M Brody
, Phoebe E Macdougall
, Carl H Schiesser

Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed.

Original language	English
Pages (from-to)	274-279
Journal	Asian Journal of Organic Chemistry
Volume	1
Issue number	3
DOIs	https://doi.org/10.1002/ajoc.201200064
Publication status	Published - 2012

Keywords

Organic Chemical Synthesis
Biologically Active Molecules

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https://hdl.handle.net/1959.11/12031

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title = "Fluorescent Angiotensin AT₁ Receptor Antagonists",

abstract = "Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed.",

keywords = "Organic Chemical Synthesis, Biologically Active Molecules",

author = "Giarrusso, \{Marilena A\} and Taylor, \{Michelle K\} and James Ziogas and Brody, \{Kate M\} and Macdougall, \{Phoebe E\} and Schiesser, \{Carl H\}",

year = "2012",

doi = "10.1002/ajoc.201200064",

language = "English",

volume = "1",

pages = "274--279",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

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T1 - Fluorescent Angiotensin AT₁ Receptor Antagonists

AU - Giarrusso, Marilena A

AU - Taylor, Michelle K

AU - Ziogas, James

AU - Brody, Kate M

AU - Macdougall, Phoebe E

AU - Schiesser, Carl H

PY - 2012

Y1 - 2012

N2 - Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed.

AB - Fluorescent selective angiotensin AT₁ receptor antagonists (sartans) that contain naphthalene (6, 7, 10, and 11), anthracene (12 and 14), acenaphthene (13 and 15), and coumarin (8 and 9) substituents have been prepared and their preliminary pharmacology evaluated in Chinese hamster ovary (CHO) cell based assays. Compounds 6-15 proved to be effective sartans with pKB estimates in the range of 6.7-10.5; their potential as cellular imaging agents is also discussed.

KW - Organic Chemical Synthesis

KW - Biologically Active Molecules

U2 - 10.1002/ajoc.201200064

DO - 10.1002/ajoc.201200064

M3 - Article

SN - 2193-5807

VL - 1

SP - 274

EP - 279

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 3

ER -

Fluorescent Angiotensin AT₁ Receptor Antagonists

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Keywords

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