Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Harindra D Sathkumara; Karyna Hansen; Socorro Miranda-Hernandez; Brenda Govan; Catherine M Rush; Lars Henning; Natkunam Ketheesan; Andreas Kupz

doi:10.1128/AAC.01422-20

Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Harindra D Sathkumara, Karyna Hansen, Socorro Miranda-Hernandez, Brenda Govan, Catherine M Rush, Lars Henning, Natkunam Ketheesan, Andreas Kupz

Biomedical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

Original language	English
Article number	e01422-20
Pages (from-to)	1-5
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	1
DOIs	https://doi.org/10.1128/AAC.01422-20
Publication status	Published - 16 Dec 2020

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SDG 3 Good Health and Well-being

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https://hdl.handle.net/1959.11/46928

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title = "Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice",

abstract = "Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.",

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AU - Sathkumara, Harindra D

AU - Hansen, Karyna

AU - Miranda-Hernandez, Socorro

AU - Govan, Brenda

AU - Rush, Catherine M

AU - Henning, Lars

AU - Ketheesan, Natkunam

AU - Kupz, Andreas

PY - 2020/12/16

Y1 - 2020/12/16

N2 - Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

AB - Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here, we assessed the efficacy of metformin (MET), an antidiabetic drug, in mice infected with a very low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected nondiabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and nondiabetic individuals.

UR - https://www.scopus.com/pages/publications/85098662299

U2 - 10.1128/AAC.01422-20

DO - 10.1128/AAC.01422-20

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M1 - e01422-20

ER -

Disparate Effects of Metformin on Mycobacterium tuberculosis Infection in Diabetic and Nondiabetic Mice

Abstract

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