Design of endoperoxides with anti-'Candida' activity

Thomas D Avery; Peter I Macreadie; Ben Greatrex; Tony V Robinson; Dennis K Taylor; Ian G Macreadie

doi:10.1016/j.bmc.2006.10.021

Design of endoperoxides with anti-'Candida' activity

Thomas D Avery, Peter I Macreadie, Ben Greatrex, Tony V Robinson, Dennis K Taylor, Ian G Macreadie

Pharmacy

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

Original language	English
Pages (from-to)	36-42
Journal	Bioorganic & Medicinal Chemistry
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.bmc.2006.10.021
Publication status	Published - 2007

Keywords

Organic Chemical Synthesis
Biologically Active Molecules

Access to Document

10.1016/j.bmc.2006.10.021

https://hdl.handle.net/1959.11/9264

Handle.net

Persistent link

Cite this

@article{6af3378224934c1f89a6f52514c67fb7,

title = "Design of endoperoxides with anti-'Candida' activity",

abstract = "Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.",

keywords = "Organic Chemical Synthesis, Biologically Active Molecules",

author = "Avery, \{Thomas D\} and Macreadie, \{Peter I\} and Ben Greatrex and Robinson, \{Tony V\} and Taylor, \{Dennis K\} and Macreadie, \{Ian G\}",

year = "2007",

doi = "10.1016/j.bmc.2006.10.021",

language = "English",

volume = "15",

pages = "36--42",

journal = "Bioorganic \& Medicinal Chemistry",

issn = "0968-0896",

publisher = "Pergamon Press",

number = "1",

}

TY - JOUR

T1 - Design of endoperoxides with anti-'Candida' activity

AU - Avery, Thomas D

AU - Macreadie, Peter I

AU - Greatrex, Ben

AU - Robinson, Tony V

AU - Taylor, Dennis K

AU - Macreadie, Ian G

PY - 2007

Y1 - 2007

N2 - Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

AB - Broad antifungal structure–activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against 'Candida albicans' in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

KW - Organic Chemical Synthesis

KW - Biologically Active Molecules

UR - https://www.scopus.com/pages/publications/33750964870

U2 - 10.1016/j.bmc.2006.10.021

DO - 10.1016/j.bmc.2006.10.021

M3 - Article

SN - 0968-0896

VL - 15

SP - 36

EP - 42

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

IS - 1

ER -

Design of endoperoxides with anti-'Candida' activity

Abstract

Keywords

Access to Document

Handle.net

Fingerprint

Cite this