Cytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'

A Chicca; F Pellati; P Nieri; B Adinolfi; A Matthias; I Massarelli; S Benvenuti; E Martinotti; A M Bianucci; Kerry Bone; R Lehmann

doi:10.1038/sj.bjp.0707639

Cytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'

A Chicca, F Pellati, P Nieri, B Adinolfi, A Matthias, I Massarelli, S Benvenuti, E Martinotti, A M Bianucci, Kerry Bone, R Lehmann

School of Health

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The n-hexane extracts of the roots of three medicinally used 'Echinacea' species exhibited cytotoxic activity on human cancer cell lines, with 'Echinacea pallida' found to be the most cytotoxic. Acetylenes are present in 'E. pallida' lipophilic extracts but essentially absent in extracts from the other two species. In the present study, the cytotoxic effects of five compounds, two polyacetylenes (namely, 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3)) and three polyenes (namely, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2), pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4) and pentadeca-(8Z,13Z)-dien-11-yn-2-one (5)), isolated from the n-hexane extract of E. pallida roots by bioassay-guided fractionation, were investigated and the potential bioavailability of these compounds in the extract was studied.

Original language	English
Pages (from-to)	879-885
Journal	British Journal of Pharmacology
Volume	153
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjp.0707639
Publication status	Published - 2008

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SDG 3 Good Health and Well-being

Keywords

Complementary and Alternative Medicine

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10.1038/sj.bjp.0707639

https://hdl.handle.net/1959.11/2922

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title = "Cytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'",

abstract = "The n-hexane extracts of the roots of three medicinally used 'Echinacea' species exhibited cytotoxic activity on human cancer cell lines, with 'Echinacea pallida' found to be the most cytotoxic. Acetylenes are present in 'E. pallida' lipophilic extracts but essentially absent in extracts from the other two species. In the present study, the cytotoxic effects of five compounds, two polyacetylenes (namely, 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3)) and three polyenes (namely, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2), pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4) and pentadeca-(8Z,13Z)-dien-11-yn-2-one (5)), isolated from the n-hexane extract of E. pallida roots by bioassay-guided fractionation, were investigated and the potential bioavailability of these compounds in the extract was studied.",

keywords = "Complementary and Alternative Medicine",

author = "A Chicca and F Pellati and P Nieri and B Adinolfi and A Matthias and I Massarelli and S Benvenuti and E Martinotti and Bianucci, \{A M\} and Kerry Bone and R Lehmann",

year = "2008",

doi = "10.1038/sj.bjp.0707639",

language = "English",

volume = "153",

pages = "879--885",

journal = "British Journal of Pharmacology",

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TY - JOUR

T1 - Cytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'

AU - Chicca, A

AU - Pellati, F

AU - Nieri, P

AU - Adinolfi, B

AU - Matthias, A

AU - Massarelli, I

AU - Benvenuti, S

AU - Martinotti, E

AU - Bianucci, A M

AU - Bone, Kerry

AU - Lehmann, R

PY - 2008

Y1 - 2008

N2 - The n-hexane extracts of the roots of three medicinally used 'Echinacea' species exhibited cytotoxic activity on human cancer cell lines, with 'Echinacea pallida' found to be the most cytotoxic. Acetylenes are present in 'E. pallida' lipophilic extracts but essentially absent in extracts from the other two species. In the present study, the cytotoxic effects of five compounds, two polyacetylenes (namely, 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3)) and three polyenes (namely, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2), pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4) and pentadeca-(8Z,13Z)-dien-11-yn-2-one (5)), isolated from the n-hexane extract of E. pallida roots by bioassay-guided fractionation, were investigated and the potential bioavailability of these compounds in the extract was studied.

AB - The n-hexane extracts of the roots of three medicinally used 'Echinacea' species exhibited cytotoxic activity on human cancer cell lines, with 'Echinacea pallida' found to be the most cytotoxic. Acetylenes are present in 'E. pallida' lipophilic extracts but essentially absent in extracts from the other two species. In the present study, the cytotoxic effects of five compounds, two polyacetylenes (namely, 8-hydroxy-pentadeca-(9E)-ene-11,13-diyn-2-one (1) and pentadeca-(9E)-ene-11,13-diyne-2,8-dione (3)) and three polyenes (namely, 8-hydroxy-pentadeca-(9E,13Z)-dien-11-yn-2-one (2), pentadeca-(9E,13Z)-dien-11-yne-2,8-dione (4) and pentadeca-(8Z,13Z)-dien-11-yn-2-one (5)), isolated from the n-hexane extract of E. pallida roots by bioassay-guided fractionation, were investigated and the potential bioavailability of these compounds in the extract was studied.

KW - Complementary and Alternative Medicine

UR - https://www.scopus.com/pages/publications/40149084652

U2 - 10.1038/sj.bjp.0707639

DO - 10.1038/sj.bjp.0707639

M3 - Article

SN - 0007-1188

VL - 153

SP - 879

EP - 885

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 5

ER -

Cytotoxic activity of polyacetylenes and polyenes isolated from roots of 'Echinacea pallida'

Abstract

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