Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar; Rebecca J Sowden; Katherine D Trotter; Michelle K Taylor; David Smith; Alan R Kennedy; John Reglinski; Corinne M Spickett

doi:10.1007/s10534-015-9875-3

Copper complexes as a source of redox active MRI contrast agents

Lynsey Dunbar, Rebecca J Sowden, Katherine D Trotter, Michelle K Taylor, David Smith, Alan R Kennedy, John Reglinski, Corinne M Spickett

Chemistry

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

Original language	English
Pages (from-to)	903-912
Journal	Biometals
Volume	28
Issue number	5
DOIs	https://doi.org/10.1007/s10534-015-9875-3
Publication status	Published - 2015

Keywords

Bioinorganic Chemistry
Medicinal and Biomolecular Chemistry
Transition Metal Chemistry

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https://hdl.handle.net/1959.11/18234

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title = "Copper complexes as a source of redox active MRI contrast agents",

abstract = "The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.",

keywords = "Bioinorganic Chemistry, Medicinal and Biomolecular Chemistry, Transition Metal Chemistry",

author = "Lynsey Dunbar and Sowden, \{Rebecca J\} and Trotter, \{Katherine D\} and Taylor, \{Michelle K\} and David Smith and Kennedy, \{Alan R\} and John Reglinski and Spickett, \{Corinne M\}",

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AU - Dunbar, Lynsey

AU - Sowden, Rebecca J

AU - Trotter, Katherine D

AU - Taylor, Michelle K

AU - Smith, David

AU - Kennedy, Alan R

AU - Reglinski, John

AU - Spickett, Corinne M

PY - 2015

Y1 - 2015

N2 - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

AB - The study reports an advance in designing copper-based redox sensing MRI contrast agents. Although the data demonstrate that copper(II) complexes are not able to compete with lanthanoids species in terms of contrast, the redox-dependent switch between diamagnetic copper(I) and paramagnetic copper(II) yields a novel redox-sensitive contrast moiety with potential for reversibility.

KW - Bioinorganic Chemistry

KW - Medicinal and Biomolecular Chemistry

KW - Transition Metal Chemistry

UR - https://www.scopus.com/pages/publications/84941995272

U2 - 10.1007/s10534-015-9875-3

DO - 10.1007/s10534-015-9875-3

M3 - Article

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VL - 28

SP - 903

EP - 912

JO - Biometals

JF - Biometals

IS - 5

ER -

Copper complexes as a source of redox active MRI contrast agents

Abstract

Keywords

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