Confirmation and dissection of QTL controlling resistance to malaria in mice

Maria Hernandez-Valladares; Jan Naessens; John Paul Gibson; Anthony J Musoke; Sonal Nagda; Pascal Rihet; Onesmo K ole-MoiYoi; Fuad A Iraqi

doi:10.1007/s00335-004-3042-4

Confirmation and dissection of QTL controlling resistance to malaria in mice

Maria Hernandez-Valladares, Jan Naessens, John Paul Gibson, Anthony J Musoke, Sonal Nagda, Pascal Rihet, Onesmo K ole-MoiYoi, Fuad A Iraqi

Faculty of Science, Ag, Business and Law

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We developed an F₁₁ AIL population from an F₁ cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F₁₁ mice were challenged with P.c. 'chabaudi' 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F₂ populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.

Original language	English
Pages (from-to)	390-398
Journal	Mammalian Genome
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/s00335-004-3042-4
Publication status	Published - 2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animal Breeding

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https://hdl.handle.net/1959.11/3257

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title = "Confirmation and dissection of QTL controlling resistance to malaria in mice",

abstract = "We developed an F₁₁ AIL population from an F₁ cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F₁₁ mice were challenged with P.c. 'chabaudi' 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F₂ populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.",

keywords = "Animal Breeding",

author = "Maria Hernandez-Valladares and Jan Naessens and Gibson, \{John Paul\} and Musoke, \{Anthony J\} and Sonal Nagda and Pascal Rihet and ole-MoiYoi, \{Onesmo K\} and Iraqi, \{Fuad A\}",

year = "2004",

doi = "10.1007/s00335-004-3042-4",

language = "English",

volume = "15",

pages = "390--398",

journal = "Mammalian Genome",

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TY - JOUR

T1 - Confirmation and dissection of QTL controlling resistance to malaria in mice

AU - Hernandez-Valladares, Maria

AU - Naessens, Jan

AU - Gibson, John Paul

AU - Musoke, Anthony J

AU - Nagda, Sonal

AU - Rihet, Pascal

AU - ole-MoiYoi, Onesmo K

AU - Iraqi, Fuad A

PY - 2004

Y1 - 2004

N2 - We developed an F₁₁ AIL population from an F₁ cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F₁₁ mice were challenged with P.c. 'chabaudi' 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F₂ populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.

AB - We developed an F₁₁ AIL population from an F₁ cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F₁₁ mice were challenged with P.c. 'chabaudi' 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F₂ populations were confirmed on the three chromosomes within narrower genomic regions, by maximum likelihood and regression analyses. Each of the previously mapped QTL on Chrs 5 and 17 resolved into two linked QTLs. The distal and proximal QTLs on Chrs 5 and 17, respectively, map to the previously reported QTL.

KW - Animal Breeding

UR - https://www.scopus.com/pages/publications/2342520650

U2 - 10.1007/s00335-004-3042-4

DO - 10.1007/s00335-004-3042-4

M3 - Article

SN - 0938-8990

VL - 15

SP - 390

EP - 398

JO - Mammalian Genome

JF - Mammalian Genome

IS - 5

ER -

Confirmation and dissection of QTL controlling resistance to malaria in mice

Abstract

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