Cofilin and profilin: partners in cancer aggressiveness

Joelle V F Coumans; Rhonda J Davey; Pierre D J Moens

doi:10.1007/s12551-018-0445-0

Cofilin and profilin: partners in cancer aggressiveness

Joelle V F Coumans
, Rhonda J Davey
, Pierre D J Moens

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P₂ binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.

Original language	English
Pages (from-to)	1323-1335
Journal	Biophysical Reviews
Volume	10
Issue number	5
Early online date	19 Jul 2018
DOIs	https://doi.org/10.1007/s12551-018-0445-0
Publication status	Published - Oct 2018

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1007/s12551-018-0445-0

https://hdl.handle.net/1959.11/29521

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title = "Cofilin and profilin: partners in cancer aggressiveness",

abstract = "This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.",

author = "Coumans, \{Joelle V F\} and Davey, \{Rhonda J\} and Moens, \{Pierre D J\}",

year = "2018",

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doi = "10.1007/s12551-018-0445-0",

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AU - Davey, Rhonda J

AU - Moens, Pierre D J

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N2 - This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.

AB - This review covers aspects of cofilin and profilin regulations and their influence on actin polymerisation responsible for cell motility and metastasis. The regulation of their activity by phosphorylation and nitration, miRs, PI(4,5)P2 binding, pH, oxidative stress and post-translational modification is described. In this review, we have highlighted selected similarities, complementarities and differences between the two proteins and how their interplay affects actin filament dynamics.

U2 - 10.1007/s12551-018-0445-0

DO - 10.1007/s12551-018-0445-0

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SN - 1867-2450

VL - 10

SP - 1323

EP - 1335

JO - Biophysical Reviews

JF - Biophysical Reviews

IS - 5

ER -

Cofilin and profilin: partners in cancer aggressiveness

Abstract

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