Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming

Anjana Silva; Christopher Johnston; Sanjaya Kuruppu; Daniela Kneisz; Kalana Maduwage; Oded Kleifeld; A Ian Smith; Sisira Siribaddana; Nicholas A Buckley; Wayne C Hodgson; Geoffrey K Isbister

doi:10.1371/journal.pntd.0005172

Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming

Anjana Silva, Christopher Johnston, Sanjaya Kuruppu, Daniela Kneisz, Kalana Maduwage, Oded Kleifeld, A Ian Smith, Sisira Siribaddana, Nicholas A Buckley, Wayne C Hodgson, Geoffrey K Isbister

Biomedical Science

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33 Citations (Scopus)

Abstract

Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antivenom and the toxins responsible for myotoxicity.

Original language	English
Article number	e0005172
Pages (from-to)	1-18
Journal	PLoS neglected tropical diseases
Volume	10
Issue number	12
DOIs	https://doi.org/10.1371/journal.pntd.0005172
Publication status	Published - 2 Dec 2016

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Silva, A., Johnston, C., Kuruppu, S., Kneisz, D., Maduwage, K., Kleifeld, O., Smith, A. I., Siribaddana, S., Buckley, N. A., Hodgson, W. C., & Isbister, G. K. (2016). Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming. PLoS neglected tropical diseases, 10(12), 1-18. Article e0005172. https://doi.org/10.1371/journal.pntd.0005172

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Silva, A, Johnston, C, Kuruppu, S, Kneisz, D, Maduwage, K, Kleifeld, O, Smith, AI, Siribaddana, S, Buckley, NA, Hodgson, WC & Isbister, GK 2016, 'Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming', PLoS neglected tropical diseases, vol. 10, no. 12, e0005172, pp. 1-18. https://doi.org/10.1371/journal.pntd.0005172

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AU - Maduwage, Kalana

AU - Kleifeld, Oded

AU - Smith, A Ian

AU - Siribaddana, Sisira

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AU - Hodgson, Wayne C

AU - Isbister, Geoffrey K

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AB - Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This study aimed to investigate evidence of myotoxicity in Russell's viper envenoming, response to antivenom and the toxins responsible for myotoxicity.

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Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming

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