Anti-mycobacterial activity of a bis-sulfonamide

Brendan Wilkinson; Laurent F Bornaghi; Anthony D Wright; Todd A Houston; Sally-Ann Poulsen

doi:10.1016/j.bmcl.2006.11.079

Anti-mycobacterial activity of a bis-sulfonamide

Brendan Wilkinson
, Laurent F Bornaghi
, Anthony D Wright
, Todd A Houston
, Sally-Ann Poulsen

Chemistry

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 μg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.

Original language	English
Pages (from-to)	1355-1357
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2006.11.079
Publication status	Published - 31 Dec 2007

Keywords

Medicinal and Biomolecular Chemistry
Biologically Active Molecules
Organic Chemical Synthesis

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https://hdl.handle.net/1959.11/22914

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title = "Anti-mycobacterial activity of a bis-sulfonamide",

abstract = "A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 μg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.",

keywords = "Medicinal and Biomolecular Chemistry, Biologically Active Molecules, Organic Chemical Synthesis",

author = "Brendan Wilkinson and Bornaghi, \{Laurent F\} and Wright, \{Anthony D\} and Houston, \{Todd A\} and Sally-Ann Poulsen",

year = "2007",

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doi = "10.1016/j.bmcl.2006.11.079",

language = "English",

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journal = "Bioorganic \& Medicinal Chemistry Letters",

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T1 - Anti-mycobacterial activity of a bis-sulfonamide

AU - Wilkinson, Brendan

AU - Bornaghi, Laurent F

AU - Wright, Anthony D

AU - Houston, Todd A

AU - Poulsen, Sally-Ann

PY - 2007/12/31

Y1 - 2007/12/31

N2 - A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 μg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.

AB - A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 μg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.

KW - Medicinal and Biomolecular Chemistry

KW - Biologically Active Molecules

KW - Organic Chemical Synthesis

U2 - 10.1016/j.bmcl.2006.11.079

DO - 10.1016/j.bmcl.2006.11.079

M3 - Article

SN - 0960-894X

VL - 17

SP - 1355

EP - 1357

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 5

ER -

Anti-mycobacterial activity of a bis-sulfonamide

Abstract

Keywords

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