Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

L Agnew; M Kelly; J Howard; S Jeganathan; M Batterham; R Ffrench; J Gold; K Watson

Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

L Agnew
, M Kelly
, J Howard
, S Jeganathan
, M Batterham
, R Ffrench
, J Gold
, K Watson

School of Science & Technology

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.

Original language	English
Pages (from-to)	1985-1988
Journal	AIDS
Volume	17
Issue number	13
Publication status	Published - 2003

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cellular Immunology

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@article{82d26510397f43089e0393ef456eccc7,

title = "Altered lymphocyte heat shock protein 70 expression in patients with HIV disease",

abstract = "Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.",

keywords = "Cellular Immunology",

author = "L Agnew and M Kelly and J Howard and S Jeganathan and M Batterham and R Ffrench and J Gold and K Watson",

year = "2003",

language = "English",

volume = "17",

pages = "1985--1988",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams \& Wilkins",

number = "13",

}

TY - JOUR

T1 - Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

AU - Agnew, L

AU - Kelly, M

AU - Howard, J

AU - Jeganathan, S

AU - Batterham, M

AU - Ffrench, R

AU - Gold, J

AU - Watson, K

PY - 2003

Y1 - 2003

N2 - Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.

AB - Heat shock protein (HSP) expression in lymphocytesisolated from 20 patients with HIV diseaseand 15 age-matched controls was determined.Fold increases in lymphocyte hsp70 expressionafter heat shock were 4.52 ± 2.97 in HIV-positiveindividuals compared with 2.60 ± 1.29 for HIV-negativecontrols (P = 0.001). Given clear rolesfor HSP in the cross-presentation of antigens, α-defensininternalization and pro-inflammatorycytokine production, a further investigation ofHSP in HIV patients is merited.

KW - Cellular Immunology

UR - http://www.aidsonline.com/

M3 - Article

SN - 0269-9370

VL - 17

SP - 1985

EP - 1988

JO - AIDS

JF - AIDS

IS - 13

ER -

Altered lymphocyte heat shock protein 70 expression in patients with HIV disease

Abstract

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