A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families

Hawlader A Al-Mamun; Paul H Kwan; Ross L Tellam; James W Kijas; Cedric Gondro

A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families

Hawlader A Al-Mamun, Paul H Kwan, Ross L Tellam, James W Kijas, Cedric Gondro

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The objective of this study was to explore the relationship between SNP and haplotype variation on gene expression traits. The data used included expression levels from 24,128 probe sets of 'logissimus lumborum' muscle from 38 half-sib Poll Dorset sheep from six families and genotypes from 49,034 SNPs collected from the same animals. The analytical approaches used sought to analyse the effects of family and haplotype blocks on conservation of gene expression traits in this sheep population. Our study indicated that there is a genetic component in gene expression traits and hence gene expression is heritable to non-negligible extent. On average, our estimated heritability for gene expression obtained from skeletal muscle samples of sheep is 0.27 and 0.29 based on two different approaches. These preliminary results are consistent with previous heritability estimates.

Original language	English
Title of host publication	Proceedings of the Association for the Advancement of Animal Breeding and Genetics
Editors	Nicolas Lopez Villalobos
Place of Publication	Armidale, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	266-269
Volume	20
ISBN (Print)	9780473260569
Publication status	Published - 2013
Event	AAABG 2013: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action - Napier, New Zealand Duration: 20 Oct 2013 → 23 Oct 2013

Conference

Conference	AAABG 2013: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action
City	Napier, New Zealand
Period	20/10/13 → 23/10/13

Keywords

Expert Systems
Gene Expression (incl Microarray and other genome-wide approaches)
Animal Breeding

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Al-Mamun, H. A., Kwan, P. H., Tellam, R. L., Kijas, J. W., & Gondro, C. (2013). A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families. In N. Lopez Villalobos (Ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics (Vol. 20, pp. 266-269). Association for the Advancement of Animal Breeding and Genetics (AAABG). https://hdl.handle.net/1959.11/13930

Al-Mamun, Hawlader A ; Kwan, Paul H ; Tellam, Ross L et al. / A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families. Proceedings of the Association for the Advancement of Animal Breeding and Genetics. editor / Nicolas Lopez Villalobos. Vol. 20 Armidale, Australia : Association for the Advancement of Animal Breeding and Genetics (AAABG), 2013. pp. 266-269

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title = "A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families",

abstract = "The objective of this study was to explore the relationship between SNP and haplotype variation on gene expression traits. The data used included expression levels from 24,128 probe sets of 'logissimus lumborum' muscle from 38 half-sib Poll Dorset sheep from six families and genotypes from 49,034 SNPs collected from the same animals. The analytical approaches used sought to analyse the effects of family and haplotype blocks on conservation of gene expression traits in this sheep population. Our study indicated that there is a genetic component in gene expression traits and hence gene expression is heritable to non-negligible extent. On average, our estimated heritability for gene expression obtained from skeletal muscle samples of sheep is 0.27 and 0.29 based on two different approaches. These preliminary results are consistent with previous heritability estimates.",

keywords = "Expert Systems, Gene Expression (incl Microarray and other genome-wide approaches), Animal Breeding",

author = "Al-Mamun, \{Hawlader A\} and Kwan, \{Paul H\} and Tellam, \{Ross L\} and Kijas, \{James W\} and Cedric Gondro",

year = "2013",

language = "English",

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booktitle = "Proceedings of the Association for the Advancement of Animal Breeding and Genetics",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

note = "AAABG 2013: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action ; Conference date: 20-10-2013 Through 23-10-2013",

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Al-Mamun, HA, Kwan, PH, Tellam, RL, Kijas, JW & Gondro, C 2013, A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families. in N Lopez Villalobos (ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics. vol. 20, Association for the Advancement of Animal Breeding and Genetics (AAABG), Armidale, Australia, pp. 266-269, AAABG 2013: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action, Napier, New Zealand, 20/10/13. <https://hdl.handle.net/1959.11/13930>

A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families. / Al-Mamun, Hawlader A; Kwan, Paul H; Tellam, Ross L et al.
Proceedings of the Association for the Advancement of Animal Breeding and Genetics. ed. / Nicolas Lopez Villalobos. Vol. 20 Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2013. p. 266-269.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kwan, Paul H

AU - Tellam, Ross L

AU - Kijas, James W

AU - Gondro, Cedric

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N2 - The objective of this study was to explore the relationship between SNP and haplotype variation on gene expression traits. The data used included expression levels from 24,128 probe sets of 'logissimus lumborum' muscle from 38 half-sib Poll Dorset sheep from six families and genotypes from 49,034 SNPs collected from the same animals. The analytical approaches used sought to analyse the effects of family and haplotype blocks on conservation of gene expression traits in this sheep population. Our study indicated that there is a genetic component in gene expression traits and hence gene expression is heritable to non-negligible extent. On average, our estimated heritability for gene expression obtained from skeletal muscle samples of sheep is 0.27 and 0.29 based on two different approaches. These preliminary results are consistent with previous heritability estimates.

AB - The objective of this study was to explore the relationship between SNP and haplotype variation on gene expression traits. The data used included expression levels from 24,128 probe sets of 'logissimus lumborum' muscle from 38 half-sib Poll Dorset sheep from six families and genotypes from 49,034 SNPs collected from the same animals. The analytical approaches used sought to analyse the effects of family and haplotype blocks on conservation of gene expression traits in this sheep population. Our study indicated that there is a genetic component in gene expression traits and hence gene expression is heritable to non-negligible extent. On average, our estimated heritability for gene expression obtained from skeletal muscle samples of sheep is 0.27 and 0.29 based on two different approaches. These preliminary results are consistent with previous heritability estimates.

KW - Expert Systems

KW - Gene Expression (incl Microarray and other genome-wide approaches)

KW - Animal Breeding

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SN - 9780473260569

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PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

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T2 - AAABG 2013: 20th Conference of the Association for the Advancement of Animal Breeding and Genetics: Translating Science into Action

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ER -

Al-Mamun HA, Kwan PH, Tellam RL, Kijas JW, Gondro C. A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families. In Lopez Villalobos N, editor, Proceedings of the Association for the Advancement of Animal Breeding and Genetics. Vol. 20. Armidale, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG). 2013. p. 266-269

A Study on Effects of Family and Haplotype Blocks on Conservation of Gene Expression Traits in Half Sib Sheep Families

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