A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance

B Kinghorn

A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance

B Kinghorn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

This paper presents a simple method to infer mode of inheritance, penetrance values, allele frequency andgenotype probabilities for a putative biallelic gene that affects a trait with all-or-none expression.Penetrance is assumed to be unaffected by other genes. The preliminary analysis tests the method in avariety of scenarios. Results can be unreliable for data generated with overdominance plus partialpenetrance, but otherwise results were good, with mode of inheritance, allele frequency and penetranceestimated close to true values. The method will work for multiple mutually-exclusive phenotypic classes.

Original language	English
Title of host publication	Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15
Editors	Linda Hygate
Place of Publication	Melbourne, Australia
Publisher	Association for the Advancement of Animal Breeding and Genetics (AAABG)
Pages	103-106
Volume	15
ISBN (Print)	0958629927
Publication status	Published - 2003
Event	AAABG 2003: 15th Conference of the Association for the Advancement of Animal Breeding and Genetics - Melbourne, Australia Duration: 7 Jul 2003 → 11 Jul 2003

Conference

Conference	AAABG 2003: 15th Conference of the Association for the Advancement of Animal Breeding and Genetics
City	Melbourne, Australia
Period	7/07/03 → 11/07/03

Keywords

Animal Breeding

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https://hdl.handle.net/1959.11/1073

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Kinghorn, B. (2003). A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance. In L. Hygate (Ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15 (Vol. 15, pp. 103-106). Association for the Advancement of Animal Breeding and Genetics (AAABG). https://hdl.handle.net/1959.11/1073

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title = "A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance",

abstract = "This paper presents a simple method to infer mode of inheritance, penetrance values, allele frequency andgenotype probabilities for a putative biallelic gene that affects a trait with all-or-none expression.Penetrance is assumed to be unaffected by other genes. The preliminary analysis tests the method in avariety of scenarios. Results can be unreliable for data generated with overdominance plus partialpenetrance, but otherwise results were good, with mode of inheritance, allele frequency and penetranceestimated close to true values. The method will work for multiple mutually-exclusive phenotypic classes.",

keywords = "Animal Breeding",

author = "B Kinghorn",

year = "2003",

language = "English",

isbn = "0958629927",

volume = "15",

pages = "103--106",

editor = "Linda Hygate",

booktitle = "Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15",

publisher = "Association for the Advancement of Animal Breeding and Genetics (AAABG)",

note = "AAABG 2003: 15th Conference of the Association for the Advancement of Animal Breeding and Genetics ; Conference date: 07-07-2003 Through 11-07-2003",

}

Kinghorn, B 2003, A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance. in L Hygate (ed.), Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15. vol. 15, Association for the Advancement of Animal Breeding and Genetics (AAABG), Melbourne, Australia, pp. 103-106, AAABG 2003: 15th Conference of the Association for the Advancement of Animal Breeding and Genetics, Melbourne, Australia, 7/07/03. <https://hdl.handle.net/1959.11/1073>

A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance. / Kinghorn, B.
Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15. ed. / Linda Hygate. Vol. 15 Melbourne, Australia: Association for the Advancement of Animal Breeding and Genetics (AAABG), 2003. p. 103-106.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kinghorn, B

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N2 - This paper presents a simple method to infer mode of inheritance, penetrance values, allele frequency andgenotype probabilities for a putative biallelic gene that affects a trait with all-or-none expression.Penetrance is assumed to be unaffected by other genes. The preliminary analysis tests the method in avariety of scenarios. Results can be unreliable for data generated with overdominance plus partialpenetrance, but otherwise results were good, with mode of inheritance, allele frequency and penetranceestimated close to true values. The method will work for multiple mutually-exclusive phenotypic classes.

AB - This paper presents a simple method to infer mode of inheritance, penetrance values, allele frequency andgenotype probabilities for a putative biallelic gene that affects a trait with all-or-none expression.Penetrance is assumed to be unaffected by other genes. The preliminary analysis tests the method in avariety of scenarios. Results can be unreliable for data generated with overdominance plus partialpenetrance, but otherwise results were good, with mode of inheritance, allele frequency and penetranceestimated close to true values. The method will work for multiple mutually-exclusive phenotypic classes.

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M3 - Conference contribution

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BT - Proceedings of the Association for the Advancement of Animal Breeding and Genetics Conference, Vol.15

A2 - Hygate, Linda

PB - Association for the Advancement of Animal Breeding and Genetics (AAABG)

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T2 - AAABG 2003: 15th Conference of the Association for the Advancement of Animal Breeding and Genetics

Y2 - 7 July 2003 through 11 July 2003

ER -

A Simple Method to Detect a Single Gene that Determines a Categorical Trait with Incomplete Penetrance

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